Catalytic, asymmetric azidations at carbonyls: achiral and meso-anhydride desymmetrisation affords enantioenriched γ-lactams

Simon N. Smith, Cristina Trujillo, Stephen J. Connon

Research output: Contribution to journalArticlepeer-review

Abstract

An unprecedented organocatalytic process involving the asymmetric addition of azide to meso-anhydrides has been developed, promoted by novel sulfamide-substituted Cinchona alkaloid-based catalysts. Readily available glutaric anhydrides can be smoothly converted to enantioenriched hemi-acyl azides and from there to either γ-amino acids or γ-lactams.

Original languageEnglish
Pages (from-to)6384-6393
Number of pages10
JournalOrganic and Biomolecular Chemistry
Volume20
Issue number32
DOIs
Publication statusPublished - 21 Jul 2022

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