Abstract
In the presence of a trityl-substituted cinchona alkaloid-based catalyst, homophthalic, aryl succinic, and glutaconic anhydride derivatives reacted with aromatic and aliphatic aldehydes to produce cis-lactones in up to 90:10 dr and 99% ee. A DFT study has shown how the catalyst is uniquely able to bring about the opposite sense of diastereocontrol to that usually observed.
Original language | English |
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Pages (from-to) | 15499-15511 |
Number of pages | 13 |
Journal | Journal of Organic Chemistry |
Volume | 83 |
Issue number | 24 |
Early online date | 21 Nov 2018 |
DOIs | |
Publication status | Published - 21 Dec 2018 |