Catalytic bio-chemo and bio-bio tandem oxidation reactions for amide and carboxylic acid synthesis

Beatrice Bechi; Susanne Herter; Shane McKenna; Christopher Riley; Silke LeimkÃÂ¼hler; Nicholas J. Turner; Andrew J. Carnell

doi:10.1039/C4GC01321B

Catalytic bio-chemo and bio-bio tandem oxidation reactions for amide and carboxylic acid synthesis

Beatrice Bechi
, Susanne Herter
, Shane McKenna
, Christopher Riley
, Silke LeimkÃÂ¼hler
, Nicholas J. Turner
, Andrew J. Carnell

Research output: Contribution to journal › Article › peer-review

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Abstract

A catalytic toolbox for three different water-based one-pot cascades to convert aryl alcohols to amides and acids and cyclic amines to lactams, involving combination of oxidative enzymes (monoamine oxidase, xanthine dehydrogenase, galactose oxidase and laccase) and chemical oxidants (TBHP or CuI(cat)/H2O2) at mild temperatures, is presented. Mutually compatible conditions were found to afford products in good to excellent yields.

Original language	English
Article number	C4GC01321B
Pages (from-to)	4524-4529
Number of pages	5
Journal	Green Chemistry
Volume	16
DOIs	https://doi.org/10.1039/C4GC01321B
Publication status	Published - 18 Aug 2014

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10.1039/C4GC01321B

POST-PEER-REVIEW-NON-PUBLISHERS.DOCXAccepted author manuscript, 1.91 MB

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title = "Catalytic bio-chemo and bio-bio tandem oxidation reactions for amide and carboxylic acid synthesis",

abstract = "A catalytic toolbox for three different water-based one-pot cascades to convert aryl alcohols to amides and acids and cyclic amines to lactams, involving combination of oxidative enzymes (monoamine oxidase, xanthine dehydrogenase, galactose oxidase and laccase) and chemical oxidants (TBHP or CuI(cat)/H2O2) at mild temperatures, is presented. Mutually compatible conditions were found to afford products in good to excellent yields.",

author = "Beatrice Bechi and Susanne Herter and Shane McKenna and Christopher Riley and Silke Leimk{\~A}{\^A}¼hler and Turner, \{Nicholas J.\} and Carnell, \{Andrew J.\}",

note = "This paper is presented as part of CHEM21 under the Innovative Medicines Initiative Joint Undertaking under the grant agreement no. 115360, resources of which are composed of financial contribution from the European Union's Seventh Framework Program (F7/2007-2013) and EFPIA companies' in-kind contributions. We also thank the Engineering and Physical Sciences Research Council (EPSRC) for funding.",

year = "2014",

month = aug,

day = "18",

doi = "10.1039/C4GC01321B",

language = "English",

volume = "16",

pages = "4524--4529",

journal = "Green Chemistry",

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T1 - Catalytic bio-chemo and bio-bio tandem oxidation reactions for amide and carboxylic acid synthesis

AU - Bechi, Beatrice

AU - Herter, Susanne

AU - McKenna, Shane

AU - Riley, Christopher

AU - LeimkÃÂ¼hler, Silke

AU - Turner, Nicholas J.

AU - Carnell, Andrew J.

N1 - This paper is presented as part of CHEM21 under the Innovative Medicines Initiative Joint Undertaking under the grant agreement no. 115360, resources of which are composed of financial contribution from the European Union's Seventh Framework Program (F7/2007-2013) and EFPIA companies' in-kind contributions. We also thank the Engineering and Physical Sciences Research Council (EPSRC) for funding.

PY - 2014/8/18

Y1 - 2014/8/18

N2 - A catalytic toolbox for three different water-based one-pot cascades to convert aryl alcohols to amides and acids and cyclic amines to lactams, involving combination of oxidative enzymes (monoamine oxidase, xanthine dehydrogenase, galactose oxidase and laccase) and chemical oxidants (TBHP or CuI(cat)/H2O2) at mild temperatures, is presented. Mutually compatible conditions were found to afford products in good to excellent yields.

AB - A catalytic toolbox for three different water-based one-pot cascades to convert aryl alcohols to amides and acids and cyclic amines to lactams, involving combination of oxidative enzymes (monoamine oxidase, xanthine dehydrogenase, galactose oxidase and laccase) and chemical oxidants (TBHP or CuI(cat)/H2O2) at mild temperatures, is presented. Mutually compatible conditions were found to afford products in good to excellent yields.

U2 - 10.1039/C4GC01321B

DO - 10.1039/C4GC01321B

M3 - Article

SN - 1463-9270

VL - 16

SP - 4524

EP - 4529

JO - Green Chemistry

JF - Green Chemistry

M1 - C4GC01321B

ER -

Catalytic bio-chemo and bio-bio tandem oxidation reactions for amide and carboxylic acid synthesis

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