Catalytic reduction of amides to amines by electrophilic phosphonium cations via FLP hydrosilylation

Meera Mehta, Alessandra Augurusa, Manuel Perez, Jiangtao Zhu, Douglas W. Stephan

Research output: Contribution to journalArticlepeer-review

Abstract

A catalytic methodology for the conversion of amides to amines is reported. Of the 25 examples described, 14 examples involve the reduction of N-trifluoroacetamides to the corresponding trifluoroethylamines. These reductions are achieved by catalytic hydrosilylation of the amide mediated by an electrophilic phosphonium cation (EPC) catalyst.
Original languageEnglish
Pages (from-to)12195-12198
Number of pages4
JournalChemical Communications
Volume52
Issue number82
Early online date13 Sept 2016
DOIs
Publication statusPublished - 2016

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