Catalytic Staudinger-Vilarrasa Reaction for the Direct Ligation of Carboxylic Acids and Azides: Journal of Organic Chemistry

J. Bures, M. Martin, F. Urpi, J. Vilarrasa

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    Abstract

    2,2'-Dipyridyl diselenide (PySeSePy) is the catalyst or activator of choice for the direct reaction of carboxylic acids with azides and trimethylphosphine at room temperature. The mechanism of the process, which is not an aza-Wittig reaction, has been elucidated.
    Original languageEnglish
    Pages (from-to)2203-2206
    Number of pages4
    JournalThe Journal of organic chemistry
    Volume74
    DOIs
    Publication statusPublished - 2009

    Keywords

    • native chemical ligation oxidation-reduction condensation aza-wittig reaction one-pot preparation 2 redox reactions peptide synthesis synthetic tricks natural-products puromycin analogs glycosyl azides

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