Causation of chronic lymphocytic leukemia - Insights from familial disease

Richard S. Houlston, Gabrielle Sellick, Martin Yuille, Estella Matutes, Daniel Catovsky

    Research output: Contribution to journalArticlepeer-review


    In Western countries B-cell chronic lymphocytic leukemia (CLL) is the most common form of leukemia. Evidence from epidemiological studies and family studies strongly supports the notion that a subset of CLL involves inherited susceptibility. Identification of genes predisposing to CLL should be useful for diagnosis and treatment, as well as serving as a model for B-cell tumorigenesis in general. Here, we review the current status of knowledge about inherited susceptibility to CLL. © 2003 Elsevier Science Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)871-876
    Number of pages5
    JournalLeukemia Research
    Issue number10
    Publication statusPublished - 1 Oct 2003


    • Chronic lymphocytic leukemia
    • Inherited susceptibility


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