Causes and therapy of hyperinsulinism in infancy

Karen E. Cosgrove; Ruth M. Shepherd; Eva M. Fernandez; Anuja Natarajan; Mark J. Dunne

doi:10.1097/00060793-200402000-00008

Causes and therapy of hyperinsulinism in infancy

Karen E. Cosgrove, Ruth M. Shepherd, Eva M. Fernandez, Anuja Natarajan, Mark J. Dunne

Research output: Contribution to journal › Article › peer-review

Abstract

Hyperinsulinism in infancy is a potentially lethal condition of neonates and occurs during early childhood as well. From defects in ion channel subunit genes to lesions in the control of β-cell metabolism and anaplerosis, the causes of hyperinsulinism in infancy are both varied and numerous. However, in all cases they appear to share a common target protein: the ATP-sensitive K + channel. This review focuses on the relation between causes of hyperinsulinism in infancy and current treatment options. © 2004 Lippincott Williams & Wilkins.

Original language	English
Pages (from-to)	31-38
Number of pages	7
Journal	Current opinion in endocrinology and diabetes
Volume	11
Issue number	1
DOIs	https://doi.org/10.1097/00060793-200402000-00008
Publication status	Published - 2004

Keywords

ATP-sensitive K+ channel
Glucokinase
Hyperinsulinism
Hypoglycaemia
Sulphonylurea receptor

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10.1097/00060793-200402000-00008

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abstract = "Hyperinsulinism in infancy is a potentially lethal condition of neonates and occurs during early childhood as well. From defects in ion channel subunit genes to lesions in the control of β-cell metabolism and anaplerosis, the causes of hyperinsulinism in infancy are both varied and numerous. However, in all cases they appear to share a common target protein: the ATP-sensitive K + channel. This review focuses on the relation between causes of hyperinsulinism in infancy and current treatment options. {\textcopyright} 2004 Lippincott Williams & Wilkins.",

keywords = "ATP-sensitive K+ channel, Glucokinase, Hyperinsulinism, Hypoglycaemia, Sulphonylurea receptor",

author = "Cosgrove, {Karen E.} and Shepherd, {Ruth M.} and Fernandez, {Eva M.} and Anuja Natarajan and Dunne, {Mark J.}",

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AU - Shepherd, Ruth M.

AU - Fernandez, Eva M.

AU - Natarajan, Anuja

AU - Dunne, Mark J.

PY - 2004

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N2 - Hyperinsulinism in infancy is a potentially lethal condition of neonates and occurs during early childhood as well. From defects in ion channel subunit genes to lesions in the control of β-cell metabolism and anaplerosis, the causes of hyperinsulinism in infancy are both varied and numerous. However, in all cases they appear to share a common target protein: the ATP-sensitive K + channel. This review focuses on the relation between causes of hyperinsulinism in infancy and current treatment options. © 2004 Lippincott Williams & Wilkins.

AB - Hyperinsulinism in infancy is a potentially lethal condition of neonates and occurs during early childhood as well. From defects in ion channel subunit genes to lesions in the control of β-cell metabolism and anaplerosis, the causes of hyperinsulinism in infancy are both varied and numerous. However, in all cases they appear to share a common target protein: the ATP-sensitive K + channel. This review focuses on the relation between causes of hyperinsulinism in infancy and current treatment options. © 2004 Lippincott Williams & Wilkins.

KW - ATP-sensitive K+ channel

KW - Glucokinase

KW - Hyperinsulinism

KW - Hypoglycaemia

KW - Sulphonylurea receptor

U2 - 10.1097/00060793-200402000-00008

DO - 10.1097/00060793-200402000-00008

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EP - 38

JO - Current opinion in endocrinology and diabetes

JF - Current opinion in endocrinology and diabetes

IS - 1

ER -

Causes and therapy of hyperinsulinism in infancy

Abstract

Keywords

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