Causes of death in patients with multiple sclerosis and matched referent subjects: a population-based cohort study.

A Lalmohamed; M T Bazelier; T P Van Staa; B M J Uitdehaag; H G M Leufkens; A De Boer; F De Vries

doi:10.1111/j.1468-1331.2012.03668.x

Causes of death in patients with multiple sclerosis and matched referent subjects: a population-based cohort study.

A Lalmohamed, M T Bazelier, T P Van Staa, B M J Uitdehaag, H G M Leufkens, A De Boer, F De Vries

Research output: Contribution to journal › Article › peer-review

Abstract

BACKGROUND AND PURPOSE: Multiple sclerosis (MS) has been associated with increased mortality rates. However, influence of lifestyle parameters remains unknown, and inconsistencies exist regarding findings for causes of death. METHODS: We conducted a population-based cohort study using the General Practice Research Database, Hospital Episode Statistics, and national death certificates (January 2001 through March 2008). To each patient with MS (n = 1270), up to six referent subjects without MS were matched by age, gender, and practice. Cox proportional hazards models were used to estimate mortality rate ratios (HRs). RESULTS: Patients with MS had a 3.5-fold increased mortality rate for all-cause mortality, compared with referent subjects (HR 3.51, 95% CI 2.63-4.69). The rate further increased amongst current smokers (HR 6.72, 95% CI 4.16-10.87) (but not in ex-smokers) and subjects with a body mass index of

Original language	English
Journal	European journal of neurology : the official journal of the European Federation of Neurological Societies
Volume	19
Issue number	7
DOIs	https://doi.org/10.1111/j.1468-1331.2012.03668.x
Publication status	Published - Jul 2012

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Lalmohamed, A., Bazelier, M. T., Van Staa, T. P., Uitdehaag, B. M. J., Leufkens, H. G. M., De Boer, A., & De Vries, F. (2012). Causes of death in patients with multiple sclerosis and matched referent subjects: a population-based cohort study. European journal of neurology : the official journal of the European Federation of Neurological Societies, 19(7). https://doi.org/10.1111/j.1468-1331.2012.03668.x

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title = "Causes of death in patients with multiple sclerosis and matched referent subjects: a population-based cohort study.",

abstract = "BACKGROUND AND PURPOSE: Multiple sclerosis (MS) has been associated with increased mortality rates. However, influence of lifestyle parameters remains unknown, and inconsistencies exist regarding findings for causes of death. METHODS: We conducted a population-based cohort study using the General Practice Research Database, Hospital Episode Statistics, and national death certificates (January 2001 through March 2008). To each patient with MS (n = 1270), up to six referent subjects without MS were matched by age, gender, and practice. Cox proportional hazards models were used to estimate mortality rate ratios (HRs). RESULTS: Patients with MS had a 3.5-fold increased mortality rate for all-cause mortality, compared with referent subjects (HR 3.51, 95% CI 2.63-4.69). The rate further increased amongst current smokers (HR 6.72, 95% CI 4.16-10.87) (but not in ex-smokers) and subjects with a body mass index of",

author = "A Lalmohamed and Bazelier, {M T} and {Van Staa}, {T P} and Uitdehaag, {B M J} and Leufkens, {H G M} and {De Boer}, A and {De Vries}, F",

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language = "English",

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Lalmohamed, A, Bazelier, MT, Van Staa, TP, Uitdehaag, BMJ, Leufkens, HGM, De Boer, A & De Vries, F 2012, 'Causes of death in patients with multiple sclerosis and matched referent subjects: a population-based cohort study.', European journal of neurology : the official journal of the European Federation of Neurological Societies, vol. 19, no. 7. https://doi.org/10.1111/j.1468-1331.2012.03668.x

Causes of death in patients with multiple sclerosis and matched referent subjects: a population-based cohort study. / Lalmohamed, A; Bazelier, M T; Van Staa, T P et al.
In: European journal of neurology : the official journal of the European Federation of Neurological Societies, Vol. 19, No. 7, 07.2012.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Causes of death in patients with multiple sclerosis and matched referent subjects: a population-based cohort study.

AU - Lalmohamed, A

AU - Bazelier, M T

AU - Van Staa, T P

AU - Uitdehaag, B M J

AU - Leufkens, H G M

AU - De Boer, A

AU - De Vries, F

PY - 2012/7

Y1 - 2012/7

N2 - BACKGROUND AND PURPOSE: Multiple sclerosis (MS) has been associated with increased mortality rates. However, influence of lifestyle parameters remains unknown, and inconsistencies exist regarding findings for causes of death. METHODS: We conducted a population-based cohort study using the General Practice Research Database, Hospital Episode Statistics, and national death certificates (January 2001 through March 2008). To each patient with MS (n = 1270), up to six referent subjects without MS were matched by age, gender, and practice. Cox proportional hazards models were used to estimate mortality rate ratios (HRs). RESULTS: Patients with MS had a 3.5-fold increased mortality rate for all-cause mortality, compared with referent subjects (HR 3.51, 95% CI 2.63-4.69). The rate further increased amongst current smokers (HR 6.72, 95% CI 4.16-10.87) (but not in ex-smokers) and subjects with a body mass index of

AB - BACKGROUND AND PURPOSE: Multiple sclerosis (MS) has been associated with increased mortality rates. However, influence of lifestyle parameters remains unknown, and inconsistencies exist regarding findings for causes of death. METHODS: We conducted a population-based cohort study using the General Practice Research Database, Hospital Episode Statistics, and national death certificates (January 2001 through March 2008). To each patient with MS (n = 1270), up to six referent subjects without MS were matched by age, gender, and practice. Cox proportional hazards models were used to estimate mortality rate ratios (HRs). RESULTS: Patients with MS had a 3.5-fold increased mortality rate for all-cause mortality, compared with referent subjects (HR 3.51, 95% CI 2.63-4.69). The rate further increased amongst current smokers (HR 6.72, 95% CI 4.16-10.87) (but not in ex-smokers) and subjects with a body mass index of

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SN - 1468-1331

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JO - European journal of neurology : the official journal of the European Federation of Neurological Societies

JF - European journal of neurology : the official journal of the European Federation of Neurological Societies

IS - 7

ER -

Causes of death in patients with multiple sclerosis and matched referent subjects: a population-based cohort study.

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