Caveolae and signalling in cancer.

Ubaldo E Martinez-Outschoorn; Federica Sotgia; Michael P Lisanti

doi:10.1038/nrc3915

Caveolae and signalling in cancer.

Ubaldo E Martinez-Outschoorn, Federica Sotgia, Michael P Lisanti

Research output: Contribution to journal › Article › peer-review

Abstract

It has been over 20 years since the discovery that caveolar lipid rafts function as signalling organelles. Lipid rafts create plasma membrane heterogeneity, and caveolae are the most extensively studied subset of lipid rafts. A newly emerging paradigm is that changes in caveolae also generate tumour metabolic heterogeneity. Altered caveolae create a catabolic tumour microenvironment, which supports oxidative mitochondrial metabolism in cancer cells and which contributes to dismal survival rates for cancer patients. In this Review, we discuss the role of caveolae in tumour progression, with a special emphasis on their metabolic and cell signalling effects, and their capacity to transform the tumour microenvironment.

Original language	English
Journal	Nature Reviews. Cancer
Volume	15
Issue number	4
DOIs	https://doi.org/10.1038/nrc3915
Publication status	Published - Apr 2015

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abstract = "It has been over 20 years since the discovery that caveolar lipid rafts function as signalling organelles. Lipid rafts create plasma membrane heterogeneity, and caveolae are the most extensively studied subset of lipid rafts. A newly emerging paradigm is that changes in caveolae also generate tumour metabolic heterogeneity. Altered caveolae create a catabolic tumour microenvironment, which supports oxidative mitochondrial metabolism in cancer cells and which contributes to dismal survival rates for cancer patients. In this Review, we discuss the role of caveolae in tumour progression, with a special emphasis on their metabolic and cell signalling effects, and their capacity to transform the tumour microenvironment.",

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Caveolae and signalling in cancer.

Abstract

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