Caveolin-1 and breast cancer: A new clinical perspective

Isabelle Mercier; Michael P. Lisanti

doi:10.1007/978-1-4614-1222-9_6

Caveolin-1 and breast cancer: A new clinical perspective

Isabelle Mercier, Michael P. Lisanti

Research output: Contribution to journal › Article › peer-review

Abstract

The current chapter focuses on the role of Caveolin-1 (Cav-1) in cellular growth with an emphasis on its implication in breast cancer initiation, progression, clinical prognosis and as a potential therapeutic target. The role of Cav-1 as a tumor suppressor in breast cancer has emerged in the past few years, with dual functions on both cancer epithelium as well as the cancer stroma. Its multiple functions as a regulator of estrogen signaling and kinase activity and its newly found role as an important factor controlling the dynamic relationship between cancer epithelia and stroma position Cav-1 as a new therapeutic target for the treatment of breast cancer. © 2012 Landes Bioscience and Springer Science+Business Media.

Original language	English
Pages (from-to)	83-94
Number of pages	11
Journal	Advances in Experimental Medicine and Biology
Volume	729
DOIs	https://doi.org/10.1007/978-1-4614-1222-9_6
Publication status	Published - 2012

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10.1007/978-1-4614-1222-9_6

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abstract = "The current chapter focuses on the role of Caveolin-1 (Cav-1) in cellular growth with an emphasis on its implication in breast cancer initiation, progression, clinical prognosis and as a potential therapeutic target. The role of Cav-1 as a tumor suppressor in breast cancer has emerged in the past few years, with dual functions on both cancer epithelium as well as the cancer stroma. Its multiple functions as a regulator of estrogen signaling and kinase activity and its newly found role as an important factor controlling the dynamic relationship between cancer epithelia and stroma position Cav-1 as a new therapeutic target for the treatment of breast cancer. {\textcopyright} 2012 Landes Bioscience and Springer Science+Business Media.",

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AB - The current chapter focuses on the role of Caveolin-1 (Cav-1) in cellular growth with an emphasis on its implication in breast cancer initiation, progression, clinical prognosis and as a potential therapeutic target. The role of Cav-1 as a tumor suppressor in breast cancer has emerged in the past few years, with dual functions on both cancer epithelium as well as the cancer stroma. Its multiple functions as a regulator of estrogen signaling and kinase activity and its newly found role as an important factor controlling the dynamic relationship between cancer epithelia and stroma position Cav-1 as a new therapeutic target for the treatment of breast cancer. © 2012 Landes Bioscience and Springer Science+Business Media.

U2 - 10.1007/978-1-4614-1222-9_6

DO - 10.1007/978-1-4614-1222-9_6

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JF - Advances in Experimental Medicine and Biology

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Caveolin-1 and breast cancer: A new clinical perspective

Abstract

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