CD3ζ-based chimeric antigen receptors mediate T cell activation via cis- and trans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy

JS Bridgeman; K Ladell; VE Sheard; K Miners; RE Hawkins; DA Price; DE Gilham

doi:10.1111/cei.12216

CD3ζ-based chimeric antigen receptors mediate T cell activation via cis- and trans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy

JS Bridgeman, K Ladell, VE Sheard, K Miners, RE Hawkins, DA Price, DE Gilham

Research output: Contribution to journal › Article › peer-review

Original language	English
Pages (from-to)	258-267
Number of pages	9
Journal	Clinical and experimental immunology
Volume	175
Issue number	2
Early online date	9 Oct 2013
DOIs	https://doi.org/10.1111/cei.12216
Publication status	Published - Feb 2014

Keywords

Gene therapy
T cells
Therapy/immunotherapy

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

Access to Document

10.1111/cei.12216

http://www.ncbi.nlm.nih.gov/pubmed/24116999

Cite this

Bridgeman, JS., Ladell, K., Sheard, VE., Miners, K., Hawkins, RE., Price, DA., & Gilham, DE. (2014). CD3ζ-based chimeric antigen receptors mediate T cell activation via cis- and trans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy. Clinical and experimental immunology, 175(2), 258-267. https://doi.org/10.1111/cei.12216

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title = "CD3ζ-based chimeric antigen receptors mediate T cell activation via cis- and trans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy",

keywords = "Gene therapy, T cells, Therapy/immunotherapy",

author = "JS Bridgeman and K Ladell and VE Sheard and K Miners and RE Hawkins and DA Price and DE Gilham",

year = "2014",

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Bridgeman, JS, Ladell, K, Sheard, VE, Miners, K, Hawkins, RE, Price, DA & Gilham, DE 2014, 'CD3ζ-based chimeric antigen receptors mediate T cell activation via cis- and trans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy', Clinical and experimental immunology, vol. 175, no. 2, pp. 258-267. https://doi.org/10.1111/cei.12216

CD3ζ-based chimeric antigen receptors mediate T cell activation via cis- and trans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy. / Bridgeman, JS; Ladell, K; Sheard, VE et al.
In: Clinical and experimental immunology, Vol. 175, No. 2, 02.2014, p. 258-267.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - CD3ζ-based chimeric antigen receptors mediate T cell activation via cis- and trans-signalling mechanisms: implications for optimization of receptor structure for adoptive cell therapy

AU - Bridgeman, JS

AU - Ladell, K

AU - Sheard, VE

AU - Miners, K

AU - Hawkins, RE

AU - Price, DA

AU - Gilham, DE

PY - 2014/2

Y1 - 2014/2

KW - Gene therapy

KW - T cells

KW - Therapy/immunotherapy

U2 - 10.1111/cei.12216

DO - 10.1111/cei.12216

M3 - Article

SN - 0009-9104

VL - 175

SP - 258

EP - 267

JO - Clinical and experimental immunology

JF - Clinical and experimental immunology

IS - 2

ER -