CD44 is expressed throughout pre-implantation human embryo development

S. Campbell, H. R. Swann, J. D. Aplin, M. W. Seif, S. J. Kimber, M. Elstein

    Research output: Contribution to journalArticlepeer-review


    The cell surface glycoprotein CD44 has been demonstrated in a variety of cell types in embryonic and adult tissues. We have established that CD44 is present on human oocytes, cumulus cells, early embryos and pre-hatched blastocysts by indirect immunofluorescence. We have also shown that CD44 is present on 8-11 week placental stroma cells, but not on the trophoblast. These findings demonstrate that CD44 is present throughout preimplantation development, and that down-regulation occurs on the embryonic surface after implantation.
    Original languageEnglish
    Pages (from-to)425-430
    Number of pages5
    JournalHuman Reproduction
    Issue number2
    Publication statusPublished - 1995


    • Adhesion molecule
    • CD44
    • Cumulus
    • Embryo
    • Oocyte


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