CD44 is expressed throughout pre-implantation human embryo development

S. Campbell; H. R. Swann; J. D. Aplin; M. W. Seif; S. J. Kimber; M. Elstein

CD44 is expressed throughout pre-implantation human embryo development

S. Campbell, H. R. Swann, J. D. Aplin, M. W. Seif, S. J. Kimber, M. Elstein

Research output: Contribution to journal › Article › peer-review

Abstract

The cell surface glycoprotein CD44 has been demonstrated in a variety of cell types in embryonic and adult tissues. We have established that CD44 is present on human oocytes, cumulus cells, early embryos and pre-hatched blastocysts by indirect immunofluorescence. We have also shown that CD44 is present on 8-11 week placental stroma cells, but not on the trophoblast. These findings demonstrate that CD44 is present throughout preimplantation development, and that down-regulation occurs on the embryonic surface after implantation.

Original language	English
Pages (from-to)	425-430
Number of pages	5
Journal	Human Reproduction
Volume	10
Issue number	2
Publication status	Published - 1995

Keywords

Adhesion molecule
CD44
Cumulus
Embryo
Oocyte

Cite this

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title = "CD44 is expressed throughout pre-implantation human embryo development",

abstract = "The cell surface glycoprotein CD44 has been demonstrated in a variety of cell types in embryonic and adult tissues. We have established that CD44 is present on human oocytes, cumulus cells, early embryos and pre-hatched blastocysts by indirect immunofluorescence. We have also shown that CD44 is present on 8-11 week placental stroma cells, but not on the trophoblast. These findings demonstrate that CD44 is present throughout preimplantation development, and that down-regulation occurs on the embryonic surface after implantation.",

keywords = "Adhesion molecule, CD44, Cumulus, Embryo, Oocyte",

author = "S. Campbell and Swann, {H. R.} and Aplin, {J. D.} and Seif, {M. W.} and Kimber, {S. J.} and M. Elstein",

year = "1995",

language = "English",

volume = "10",

pages = "425--430",

journal = "Human Reproduction",

issn = "0268-1161",

publisher = "Oxford University Press",

number = "2",

}

TY - JOUR

T1 - CD44 is expressed throughout pre-implantation human embryo development

AU - Campbell, S.

AU - Swann, H. R.

AU - Aplin, J. D.

AU - Seif, M. W.

AU - Kimber, S. J.

AU - Elstein, M.

PY - 1995

Y1 - 1995

N2 - The cell surface glycoprotein CD44 has been demonstrated in a variety of cell types in embryonic and adult tissues. We have established that CD44 is present on human oocytes, cumulus cells, early embryos and pre-hatched blastocysts by indirect immunofluorescence. We have also shown that CD44 is present on 8-11 week placental stroma cells, but not on the trophoblast. These findings demonstrate that CD44 is present throughout preimplantation development, and that down-regulation occurs on the embryonic surface after implantation.

AB - The cell surface glycoprotein CD44 has been demonstrated in a variety of cell types in embryonic and adult tissues. We have established that CD44 is present on human oocytes, cumulus cells, early embryos and pre-hatched blastocysts by indirect immunofluorescence. We have also shown that CD44 is present on 8-11 week placental stroma cells, but not on the trophoblast. These findings demonstrate that CD44 is present throughout preimplantation development, and that down-regulation occurs on the embryonic surface after implantation.

KW - Adhesion molecule

KW - CD44

KW - Cumulus

KW - Embryo

KW - Oocyte

M3 - Article

C2 - 0007539449

SN - 0268-1161

VL - 10

SP - 425

EP - 430

JO - Human Reproduction

JF - Human Reproduction

IS - 2

ER -

CD44 is expressed throughout pre-implantation human embryo development

Abstract

Keywords

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