Cdc 14 phosphatase resolves the rDNA segregation delay

Gislene Pereira; Elmar Schiebel

doi:10.1038/ncb0604-473

Cdc 14 phosphatase resolves the rDNA segregation delay

Gislene Pereira, Elmar Schiebel

Research output: Contribution to journal › Article › peer-review

Abstract

Sister chromatid segregation in anaphase of mitosis is initiated through cleavage of cohesin by the protease separase. Two studies now show that this view is valid for most chromosomal DNA, but not for the highly repetitive ribosomal DNA (rDNA) and telomeres. The disjunction of these regions of the chromosome occurs in mid-anaphase, long after cohesin cleavage, and is regulated by the conserved phosphatase Cdc14.

Original language	English
Pages (from-to)	473-475
Number of pages	2
Journal	Nature Cell Biology
Volume	6
Issue number	6
DOIs	https://doi.org/10.1038/ncb0604-473
Publication status	Published - Jun 2004

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title = "Cdc 14 phosphatase resolves the rDNA segregation delay",

abstract = "Sister chromatid segregation in anaphase of mitosis is initiated through cleavage of cohesin by the protease separase. Two studies now show that this view is valid for most chromosomal DNA, but not for the highly repetitive ribosomal DNA (rDNA) and telomeres. The disjunction of these regions of the chromosome occurs in mid-anaphase, long after cohesin cleavage, and is regulated by the conserved phosphatase Cdc14.",

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AB - Sister chromatid segregation in anaphase of mitosis is initiated through cleavage of cohesin by the protease separase. Two studies now show that this view is valid for most chromosomal DNA, but not for the highly repetitive ribosomal DNA (rDNA) and telomeres. The disjunction of these regions of the chromosome occurs in mid-anaphase, long after cohesin cleavage, and is regulated by the conserved phosphatase Cdc14.

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DO - 10.1038/ncb0604-473

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JO - Nature Cell Biology

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Cdc 14 phosphatase resolves the rDNA segregation delay

Abstract

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