Cdc 14 phosphatase resolves the rDNA segregation delay

Gislene Pereira, Elmar Schiebel

    Research output: Contribution to journalArticlepeer-review


    Sister chromatid segregation in anaphase of mitosis is initiated through cleavage of cohesin by the protease separase. Two studies now show that this view is valid for most chromosomal DNA, but not for the highly repetitive ribosomal DNA (rDNA) and telomeres. The disjunction of these regions of the chromosome occurs in mid-anaphase, long after cohesin cleavage, and is regulated by the conserved phosphatase Cdc14.
    Original languageEnglish
    Pages (from-to)473-475
    Number of pages2
    JournalNature Cell Biology
    Issue number6
    Publication statusPublished - Jun 2004


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