Cediranib monotherapy in patients with advanced renal cell carcinoma: Results of a randomised phase II study

Peter Mulders, Robert Hawkins, Paul Nathan, Igle De Jong, Susanne Osanto, Emilio Porfiri, Andrew Protheroe, Carla M L Van Herpen, Bijoyesh Mookerjee, Laura Pike, Juliane M. Jürgensmeier, Martin E. Gore

    Research output: Contribution to journalArticlepeer-review


    Background: Cediranib is a highly potent vascular endothelial growth factor (VEGF) signalling inhibitor with activity against VEGF receptors 1, 2 and 3. This Phase II, randomised, double-blind, parallel-group study compared the efficacy of cediranib with placebo in patients with metastatic or recurrent clear cell renal cell carcinoma who had not previously received a VEGF signalling inhibitor. Methods: Patients were randomised (3:1) to cediranib 45 mg/day or placebo. The primary objective was comparison of change from baseline in tumour size after 12 weeks of therapy. Secondary objectives included response rate and duration, progression-free survival (PFS) and safety and tolerability. Patients in the placebo group could cross over to open-label cediranib at 12 weeks or earlier if their disease had progressed. This study has been completed and is registered with ClinicalTrials.gov, number NCT00423332. Findings: Patients (n = 71) were randomised to receive cediranib (n = 53) or placebo (n = 18). The primary study outcome revealed that, after 12 weeks of therapy, there was a significant difference in mean percentage change from baseline in tumour size between the cediranib (-20%) and placebo (+20%) arms (p <0.0001). Eighteen patients (34%) on cediranib achieved a partial response and 25 (47%) experienced stable disease. Cediranib treatment prolonged PFS significantly compared with placebo (hazard ratio (HR) = 0.45, 90% confidence interval: 0.26-0.76, p = 0.017; median PFS 12.1 versus 2.8 months). The most common adverse events in patients receiving cediranib were diarrhoea (74%), hypertension (64%), fatigue (58%) and dysphonia (58%). Interpretation: Cediranib monotherapy demonstrated significant evidence of antitumour activity in patients with advanced renal cell carcinoma. The adverse event profile was consistent with previous studies of cediranib 45 mg. © 2011 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)527-537
    Number of pages10
    JournalEuropean Journal of Cancer
    Issue number4
    Publication statusPublished - Mar 2012


    • Cediranib
    • Monotherapy
    • Phase II
    • Renal cell carcinoma


    Dive into the research topics of 'Cediranib monotherapy in patients with advanced renal cell carcinoma: Results of a randomised phase II study'. Together they form a unique fingerprint.

    Cite this