Cell adhesion molecules as potential biomarkers of nephritis, damage and accelerated atherosclerosis in patients with SLE

S. Skeoch, Sahena Haque, P. Pemberton, I. N. Bruce

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Objectives: The aim of the current study was to compare levels of vascular cell adhesion molecule-1 (VCAM-1) and E-selectin in lupus patients and controls and to investigate their association with clinical phenotype, disease activity and damage. Methods: We compared levels of serum VCAM-1 and E-selectin in 178 female lupus patients and 69 age-and sexmatched controls. Using linear regression we also examined the association between these markers and disease activity, damage, renal and skin involvement as well as clinical and subclinical cardiovascular disease. Results: E-selectin was increased in patients compared to controls (median (IQR) 10.5 (6.85, 13.9) vs 7.86 (5.39, 10.4) ng/ml; p
    Original languageEnglish
    Pages (from-to)819-824
    Number of pages5
    JournalLupus
    Volume23
    Issue number8
    DOIs
    Publication statusPublished - Mar 2014

    Keywords

    • Cardiovascular disease
    • Cellular adhesion Molecules
    • Nephritis
    • Systemic lupus erythematosus

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