Cell and Gene Therapy for Spine Regeneration: Mammalian Protein Production Platforms for Overproduction of Therapeutic Proteins and Growth Factors

Ali Mobasheri; Stephen M. Richardson

doi:10.1016/j.nec.2019.08.015

Cell and Gene Therapy for Spine Regeneration: Mammalian Protein Production Platforms for Overproduction of Therapeutic Proteins and Growth Factors

Ali Mobasheri^*, Stephen M. Richardson

^*Corresponding author for this work

Division of Cell Matrix Biology & Regenerative Medicine (L5)

State Research Institute Centre for Innovative Medicine

Research output: Contribution to journal › Review article › peer-review

Abstract

This article provides an evidence-based personal perspective on the future of cell and gene therapy for degenerative diseases of the intervertebral disc. This paper focuses on how mammalian protein production platforms and transfected and irradiated protein packaging cell lines may be used as “cellular factories” for overproduction of therapeutic proteins and proanabolic growth factors, particularly in the context of regenerative therapies. This paper also speculates on future opportunities and challenges in this area of research and how new innovations in biotechnology affect cell and gene therapy for degenerative diseases.

Original language	English
Pages (from-to)	131-139
Number of pages	9
Journal	Neurosurgery Clinics of North America
Volume	31
Issue number	1
Early online date	15 Nov 2019
DOIs	https://doi.org/10.1016/j.nec.2019.08.015
Publication status	Published - Jan 2020

Keywords

Cell therapy
GDF6
Gene therapy
Growth factors
Low back pain (LBP)
Mammalian protein production platforms
Protein packaging cell lines
Spine degeneration
Transforming growth factor-β (TGF-β)

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10.1016/j.nec.2019.08.015

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title = "Cell and Gene Therapy for Spine Regeneration: Mammalian Protein Production Platforms for Overproduction of Therapeutic Proteins and Growth Factors",

abstract = "This article provides an evidence-based personal perspective on the future of cell and gene therapy for degenerative diseases of the intervertebral disc. This paper focuses on how mammalian protein production platforms and transfected and irradiated protein packaging cell lines may be used as “cellular factories” for overproduction of therapeutic proteins and proanabolic growth factors, particularly in the context of regenerative therapies. This paper also speculates on future opportunities and challenges in this area of research and how new innovations in biotechnology affect cell and gene therapy for degenerative diseases.",

keywords = "Cell therapy, GDF6, Gene therapy, Growth factors, Low back pain (LBP), Mammalian protein production platforms, Protein packaging cell lines, Spine degeneration, Transforming growth factor-β (TGF-β)",

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AB - This article provides an evidence-based personal perspective on the future of cell and gene therapy for degenerative diseases of the intervertebral disc. This paper focuses on how mammalian protein production platforms and transfected and irradiated protein packaging cell lines may be used as “cellular factories” for overproduction of therapeutic proteins and proanabolic growth factors, particularly in the context of regenerative therapies. This paper also speculates on future opportunities and challenges in this area of research and how new innovations in biotechnology affect cell and gene therapy for degenerative diseases.

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KW - GDF6

KW - Gene therapy

KW - Growth factors

KW - Low back pain (LBP)

KW - Mammalian protein production platforms

KW - Protein packaging cell lines

KW - Spine degeneration

KW - Transforming growth factor-β (TGF-β)

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M3 - Review article

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SN - 1042-3680

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JO - Neurosurgery Clinics of North America

JF - Neurosurgery Clinics of North America

IS - 1

ER -

Cell and Gene Therapy for Spine Regeneration: Mammalian Protein Production Platforms for Overproduction of Therapeutic Proteins and Growth Factors

Abstract

Keywords

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