Cell and Gene Therapy for Spine Regeneration: Mammalian Protein Production Platforms for Overproduction of Therapeutic Proteins and Growth Factors

Ali Mobasheri, Stephen M. Richardson

Research output: Contribution to journalReview articlepeer-review

Abstract

This article provides an evidence-based personal perspective on the future of cell and gene therapy for degenerative diseases of the intervertebral disc. This paper focuses on how mammalian protein production platforms and transfected and irradiated protein packaging cell lines may be used as “cellular factories” for overproduction of therapeutic proteins and proanabolic growth factors, particularly in the context of regenerative therapies. This paper also speculates on future opportunities and challenges in this area of research and how new innovations in biotechnology affect cell and gene therapy for degenerative diseases.

Original languageEnglish
Pages (from-to)131-139
Number of pages9
JournalNeurosurgery Clinics of North America
Volume31
Issue number1
Early online date15 Nov 2019
DOIs
Publication statusPublished - Jan 2020

Keywords

  • Cell therapy
  • GDF6
  • Gene therapy
  • Growth factors
  • Low back pain (LBP)
  • Mammalian protein production platforms
  • Protein packaging cell lines
  • Spine degeneration
  • Transforming growth factor-β (TGF-β)

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