Cell division: Spindle positioning

Holly Lovegrove; Dan T. Bergstralh

doi:10.1016/B978-0-12-819460-7.00294-2

Cell division: Spindle positioning

Holly Lovegrove, Dan T. Bergstralh

Division of Cardiovascular Sciences (L5)

University of Rochester

Research output: Chapter in Book/Conference proceeding › Chapter › peer-review

Abstract

The orientation of cell division (1) determines the position of the daughter cells after mitosis (2) directs cell fate, and (3) can influence tissue architecture. The angle of a cell division is determined by the position of the mitotic spindle. This structure is pulled into alignment by a highly conserved complex of proteins, the localization of which varies between cell types relative to a range of cellular features. Loss of division orientation in some tissues results in a disruption of tissue architecture. While other cell types are able to remove the misplaced cells via apoptosis or even reintegrate them into the tissue.

Original language	English
Title of host publication	Encyclopedia of Biological Chemistry
Editors	Joseph Jez
Place of Publication	Amsterdam, Netherlands
Publisher	Elsevier BV
Pages	68-77
Edition	3rd
ISBN (Print)	9780128194607
DOIs	https://doi.org/10.1016/B978-0-12-819460-7.00294-2
Publication status	Published - 2021

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10.1016/B978-0-12-819460-7.00294-2

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BT - Encyclopedia of Biological Chemistry

A2 - Jez, Joseph

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ER -

Cell division: Spindle positioning

Abstract

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