Cell division: Spindle positioning

Holly Lovegrove, Dan T. Bergstralh

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


The orientation of cell division (1) determines the position of the daughter cells after mitosis (2) directs cell fate, and (3) can influence tissue architecture. The angle of a cell division is determined by the position of the mitotic spindle. This structure is pulled into alignment by a highly conserved complex of proteins, the localization of which varies between cell types relative to a range of cellular features. Loss of division orientation in some tissues results in a disruption of tissue architecture. While other cell types are able to remove the misplaced cells via apoptosis or even reintegrate them into the tissue.
Original languageEnglish
Title of host publicationEncyclopedia of Biological Chemistry
EditorsJoseph Jez
Place of PublicationAmsterdam, Netherlands
PublisherElsevier BV
ISBN (Print)9780128194607
Publication statusPublished - 2021


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