Cell free hemoglobin in the fetoplacental circulation: A novel cause of fetal growth restriction?

Adam Brook; Annie Hoaksey; Rekha Gurung; Edward E.C. Yoong; Rosanna Sneyd; Georgia C. Baynes; Helen Bischof; Sarah Jones; Lucy E. Higgins; Carolyn Jones; Susan L. Greenwood; Rebecca L. Jones; Magnus Gram; Ingrid Lang; Gernot Desoye; Jenny Myers; Henning Schneider; Stefan R. Hansson; Ian P. Crocker; Paul Brownbill

doi:10.1096/fj.201800264R

Cell free hemoglobin in the fetoplacental circulation: A novel cause of fetal growth restriction?

Adam Brook
, Annie Hoaksey
, Rekha Gurung
, Edward E.C. Yoong
, Rosanna Sneyd
, Georgia C. Baynes
, Helen Bischof
, Sarah Jones
, Lucy E. Higgins
, Carolyn Jones
, Susan L. Greenwood
, Rebecca L. Jones
, Magnus Gram
, Ingrid Lang
, Gernot Desoye
, Jenny Myers
, Henning Schneider
, Stefan R. Hansson
, Ian P. Crocker
, Paul Brownbill^*

^*Corresponding author for this work

The Christie Hospital NHS Foundation Trust
Manchester Metropolitan University (MMU)
Lund University
University of Graz
University of Bern
UMIST

Research output: Contribution to journal › Article › peer-review

Abstract

© FASEB. Cell free hemoglobin impairs vascular function and blood flow in adult cardiovascular disease. In this study, we investigated the hypothesis that free fetal hemoglobin (fHbF) compromises vascular integrity and function in the fetoplacental circulation, contributing to the increased vascular resistance associated with fetal growth restriction (FGR). Women with normal and FGR pregnancies were recruited and their placentas collected freshly postpartum. FGRfetal capillaries showed evidence of erythrocyte vascular packing and extravasation. Fetal cord blood fHbF levels were higher in FGR than in normal pregnancies (P <0.05) and the elevation of fHbF in relation to heme oxygenase-1 suggests a failure of expected catabolic compensation,which occurs in adults.During ex vivo placental perfusion, pathophysiological fHbF concentrations significantly increased fetal-side microcirculatory resistance (P

Original language	English
Pages (from-to)	5436-5446
Number of pages	11
Journal	Faseb Journal
Volume	32
Issue number	10
Early online date	27 Sept 2018
DOIs	https://doi.org/10.1096/fj.201800264R
Publication status	Published - 1 Oct 2018

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Keywords

Blood-flow resistance
Endothelium
Nitric oxide
Stillbirth
Vascular compromise

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10.1096/fj.201800264R

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5097935/

Cite this

Brook, A., Hoaksey, A., Gurung, R., Yoong, E. E. C., Sneyd, R., Baynes, G. C., Bischof, H., Jones, S., Higgins, L. E., Jones, C., Greenwood, S. L., Jones, R. L., Gram, M., Lang, I., Desoye, G., Myers, J., Schneider, H., Hansson, S. R., Crocker, I. P., & Brownbill, P. (2018). Cell free hemoglobin in the fetoplacental circulation: A novel cause of fetal growth restriction? Faseb Journal, 32(10), 5436-5446. https://doi.org/10.1096/fj.201800264R

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title = "Cell free hemoglobin in the fetoplacental circulation: A novel cause of fetal growth restriction?",

abstract = "{\textcopyright} FASEB. Cell free hemoglobin impairs vascular function and blood flow in adult cardiovascular disease. In this study, we investigated the hypothesis that free fetal hemoglobin (fHbF) compromises vascular integrity and function in the fetoplacental circulation, contributing to the increased vascular resistance associated with fetal growth restriction (FGR). Women with normal and FGR pregnancies were recruited and their placentas collected freshly postpartum. FGRfetal capillaries showed evidence of erythrocyte vascular packing and extravasation. Fetal cord blood fHbF levels were higher in FGR than in normal pregnancies (P <0.05) and the elevation of fHbF in relation to heme oxygenase-1 suggests a failure of expected catabolic compensation,which occurs in adults.During ex vivo placental perfusion, pathophysiological fHbF concentrations significantly increased fetal-side microcirculatory resistance (P",

keywords = "Blood-flow resistance, Endothelium, Nitric oxide, Stillbirth, Vascular compromise",

author = "Adam Brook and Annie Hoaksey and Rekha Gurung and Yoong, \{Edward E.C.\} and Rosanna Sneyd and Baynes, \{Georgia C.\} and Helen Bischof and Sarah Jones and Higgins, \{Lucy E.\} and Carolyn Jones and Greenwood, \{Susan L.\} and Jones, \{Rebecca L.\} and Magnus Gram and Ingrid Lang and Gernot Desoye and Jenny Myers and Henning Schneider and Hansson, \{Stefan R.\} and Crocker, \{Ian P.\} and Paul Brownbill",

year = "2018",

month = oct,

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doi = "10.1096/fj.201800264R",

language = "English",

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Brook, A, Hoaksey, A, Gurung, R, Yoong, EEC, Sneyd, R, Baynes, GC, Bischof, H, Jones, S, Higgins, LE , Jones, C , Greenwood, SL, Jones, RL, Gram, M, Lang, I, Desoye, G, Myers, J, Schneider, H, Hansson, SR, Crocker, IP & Brownbill, P 2018, 'Cell free hemoglobin in the fetoplacental circulation: A novel cause of fetal growth restriction?', Faseb Journal, vol. 32, no. 10, pp. 5436-5446. https://doi.org/10.1096/fj.201800264R

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T1 - Cell free hemoglobin in the fetoplacental circulation

T2 - A novel cause of fetal growth restriction?

AU - Brook, Adam

AU - Hoaksey, Annie

AU - Gurung, Rekha

AU - Yoong, Edward E.C.

AU - Sneyd, Rosanna

AU - Baynes, Georgia C.

AU - Bischof, Helen

AU - Jones, Sarah

AU - Higgins, Lucy E.

AU - Jones, Carolyn

AU - Greenwood, Susan L.

AU - Jones, Rebecca L.

AU - Gram, Magnus

AU - Lang, Ingrid

AU - Desoye, Gernot

AU - Myers, Jenny

AU - Schneider, Henning

AU - Hansson, Stefan R.

AU - Crocker, Ian P.

AU - Brownbill, Paul

PY - 2018/10/1

Y1 - 2018/10/1

N2 - © FASEB. Cell free hemoglobin impairs vascular function and blood flow in adult cardiovascular disease. In this study, we investigated the hypothesis that free fetal hemoglobin (fHbF) compromises vascular integrity and function in the fetoplacental circulation, contributing to the increased vascular resistance associated with fetal growth restriction (FGR). Women with normal and FGR pregnancies were recruited and their placentas collected freshly postpartum. FGRfetal capillaries showed evidence of erythrocyte vascular packing and extravasation. Fetal cord blood fHbF levels were higher in FGR than in normal pregnancies (P <0.05) and the elevation of fHbF in relation to heme oxygenase-1 suggests a failure of expected catabolic compensation,which occurs in adults.During ex vivo placental perfusion, pathophysiological fHbF concentrations significantly increased fetal-side microcirculatory resistance (P

AB - © FASEB. Cell free hemoglobin impairs vascular function and blood flow in adult cardiovascular disease. In this study, we investigated the hypothesis that free fetal hemoglobin (fHbF) compromises vascular integrity and function in the fetoplacental circulation, contributing to the increased vascular resistance associated with fetal growth restriction (FGR). Women with normal and FGR pregnancies were recruited and their placentas collected freshly postpartum. FGRfetal capillaries showed evidence of erythrocyte vascular packing and extravasation. Fetal cord blood fHbF levels were higher in FGR than in normal pregnancies (P <0.05) and the elevation of fHbF in relation to heme oxygenase-1 suggests a failure of expected catabolic compensation,which occurs in adults.During ex vivo placental perfusion, pathophysiological fHbF concentrations significantly increased fetal-side microcirculatory resistance (P

KW - Blood-flow resistance

KW - Endothelium

KW - Nitric oxide

KW - Stillbirth

KW - Vascular compromise

UR - https://www.scopus.com/pages/publications/85054071145

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DO - 10.1096/fj.201800264R

M3 - Article

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SN - 0892-6638

VL - 32

SP - 5436

EP - 5446

JO - Faseb Journal

JF - Faseb Journal

IS - 10

ER -

Cell free hemoglobin in the fetoplacental circulation: A novel cause of fetal growth restriction?

Abstract

UN SDGs

Keywords

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