Cell irradiation experiment using laser driven protons at ultra high dose rate

KF Kakolee; D Doria; S Kar; S Lift; M Zepf; M Borghesi; D Kirby; F Fiorini; S Green; K Kirby; JC Jeynes; M Merchant; J Kavanagh; G Schettino

Cell irradiation experiment using laser driven protons at ultra high dose rate

KF Kakolee, D Doria, S Kar, S Lift, M Zepf, M Borghesi, D Kirby, F Fiorini, S Green, K Kirby, JC Jeynes, M Merchant, J Kavanagh, G Schettino

Research output: Chapter in Book/Conference proceeding › Conference contribution › peer-review

Abstract

The effect of proton irradiation of biological cells, on timescales orders of magnitude shorter than with conventional accelerators, has been investigated by employing the TARANIS laser at Queen's University. Multiple cell-spots with different doses and proton energies were irradiated at the same time in a single laser shot at dose rates exceeding 109 Gy/sec. The data show a clear dose-dependant lethal effect of laser-driven protons over V-79 cells. A comparison with the survival obtained with an X-Ray standard source has been done and the resulting relative biological effectiveness (RBE) is about 1.3 at 10%.

Original language	English
Title of host publication	38th EPS Conference on Plasma Physics 2011, EPS 2011 - Europhysics Conference Abstracts
Pages	133-136
Number of pages	4
Volume	35 1
Publication status	Published - 2011

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Kakolee, KF., Doria, D., Kar, S., Lift, S., Zepf, M., Borghesi, M., Kirby, D., Fiorini, F., Green, S., Kirby, K., Jeynes, JC., Merchant, M., Kavanagh, J., & Schettino, G. (2011). Cell irradiation experiment using laser driven protons at ultra high dose rate. In 38th EPS Conference on Plasma Physics 2011, EPS 2011 - Europhysics Conference Abstracts (Vol. 35 1, pp. 133-136)

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title = "Cell irradiation experiment using laser driven protons at ultra high dose rate",

abstract = "The effect of proton irradiation of biological cells, on timescales orders of magnitude shorter than with conventional accelerators, has been investigated by employing the TARANIS laser at Queen's University. Multiple cell-spots with different doses and proton energies were irradiated at the same time in a single laser shot at dose rates exceeding 109 Gy/sec. The data show a clear dose-dependant lethal effect of laser-driven protons over V-79 cells. A comparison with the survival obtained with an X-Ray standard source has been done and the resulting relative biological effectiveness (RBE) is about 1.3 at 10%.",

author = "KF Kakolee and D Doria and S Kar and S Lift and M Zepf and M Borghesi and D Kirby and F Fiorini and S Green and K Kirby and JC Jeynes and M Merchant and J Kavanagh and G Schettino",

year = "2011",

language = "English",

volume = "35 1",

pages = "133--136",

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TY - GEN

T1 - Cell irradiation experiment using laser driven protons at ultra high dose rate

AU - Kakolee, KF

AU - Doria, D

AU - Kar, S

AU - Lift, S

AU - Zepf, M

AU - Borghesi, M

AU - Kirby, D

AU - Fiorini, F

AU - Green, S

AU - Kirby, K

AU - Jeynes, JC

AU - Merchant, M

AU - Kavanagh, J

AU - Schettino, G

PY - 2011

Y1 - 2011

N2 - The effect of proton irradiation of biological cells, on timescales orders of magnitude shorter than with conventional accelerators, has been investigated by employing the TARANIS laser at Queen's University. Multiple cell-spots with different doses and proton energies were irradiated at the same time in a single laser shot at dose rates exceeding 109 Gy/sec. The data show a clear dose-dependant lethal effect of laser-driven protons over V-79 cells. A comparison with the survival obtained with an X-Ray standard source has been done and the resulting relative biological effectiveness (RBE) is about 1.3 at 10%.

AB - The effect of proton irradiation of biological cells, on timescales orders of magnitude shorter than with conventional accelerators, has been investigated by employing the TARANIS laser at Queen's University. Multiple cell-spots with different doses and proton energies were irradiated at the same time in a single laser shot at dose rates exceeding 109 Gy/sec. The data show a clear dose-dependant lethal effect of laser-driven protons over V-79 cells. A comparison with the survival obtained with an X-Ray standard source has been done and the resulting relative biological effectiveness (RBE) is about 1.3 at 10%.

M3 - Conference contribution

VL - 35 1

SP - 133

EP - 136

BT - 38th EPS Conference on Plasma Physics 2011, EPS 2011 - Europhysics Conference Abstracts

ER -

Cell irradiation experiment using laser driven protons at ultra high dose rate

Abstract

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