Cell replacement therapy and the evasion of destructive immunity

Paul J. Fairchild; Nathan J. Robertson; Siân Cartland; Kathleen F. Nolan; Herman Waldmann

doi:10.1385/SCR:1:2:159

Cell replacement therapy and the evasion of destructive immunity

Paul J. Fairchild, Nathan J. Robertson, Siân Cartland, Kathleen F. Nolan, Herman Waldmann

Research output: Contribution to journal › Article › peer-review

Abstract

The potential of human embryonic stem (ES) cells to meet the growing demand for cell types and tissues for the treatment of chronic and degenerative diseases has been widely acclaimed. Nevertheless, their use in cell replacement therapy poses a number of significant challenges, not least of which is their subsequent rejection by the recipient's immune system. Here we explore the extent of the immunological barriers encountered and evaluate the potential of different approaches to overcoming these issues of which somatic nuclear transfer (SNT) and the induction of transplanation tolerance are currently the most promising. Copyright © 2005 Humana Press Inc. All rights of any nature whatsoever are reserved.

Original language	English
Pages (from-to)	159-168
Number of pages	9
Journal	Stem cell reviews
Volume	1
Issue number	2
DOIs	https://doi.org/10.1385/SCR:1:2:159
Publication status	Published - Jun 2005

Keywords

Animals
Dendritic Cells/cytology/immunology
Embryonic Stem Cells/cytology/*immunology
Humans
*Immunity
Stem Cell Transplantation
*Tissue Therapy

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title = "Cell replacement therapy and the evasion of destructive immunity",

abstract = "The potential of human embryonic stem (ES) cells to meet the growing demand for cell types and tissues for the treatment of chronic and degenerative diseases has been widely acclaimed. Nevertheless, their use in cell replacement therapy poses a number of significant challenges, not least of which is their subsequent rejection by the recipient's immune system. Here we explore the extent of the immunological barriers encountered and evaluate the potential of different approaches to overcoming these issues of which somatic nuclear transfer (SNT) and the induction of transplanation tolerance are currently the most promising. Copyright {\textcopyright} 2005 Humana Press Inc. All rights of any nature whatsoever are reserved.",

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author = "Fairchild, {Paul J.} and Robertson, {Nathan J.} and Si{\^a}n Cartland and Nolan, {Kathleen F.} and Herman Waldmann",

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AU - Nolan, Kathleen F.

AU - Waldmann, Herman

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AB - The potential of human embryonic stem (ES) cells to meet the growing demand for cell types and tissues for the treatment of chronic and degenerative diseases has been widely acclaimed. Nevertheless, their use in cell replacement therapy poses a number of significant challenges, not least of which is their subsequent rejection by the recipient's immune system. Here we explore the extent of the immunological barriers encountered and evaluate the potential of different approaches to overcoming these issues of which somatic nuclear transfer (SNT) and the induction of transplanation tolerance are currently the most promising. Copyright © 2005 Humana Press Inc. All rights of any nature whatsoever are reserved.

KW - Animals

KW - Dendritic Cells/cytology/immunology

KW - Embryonic Stem Cells/cytology/immunology

KW - Humans

KW - Immunity

KW - Stem Cell Transplantation

KW - Tissue Therapy

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JO - Stem cell reviews

JF - Stem cell reviews

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Cell replacement therapy and the evasion of destructive immunity

Abstract

Keywords

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