Cell-specific and concentration-dependent actions of interleukin-1 in acute brain inflammation

Emmanuel Pinteaux; Paula Trotter; Anastasia Simi

doi:10.1016/j.cyto.2008.10.008

Cell-specific and concentration-dependent actions of interleukin-1 in acute brain inflammation

Emmanuel Pinteaux, Paula Trotter, Anastasia Simi

Research output: Contribution to journal › Article › peer-review

Abstract

Interleukin (IL)-1 is a pivotal pro-inflammatory cytokine and an important mediator of both acute and chronic central nervous system (CNS) injuries. Despite intense research in CNS IL-1 biology over the past two decades, its precise mechanism of action in inflammatory responses to acute brain disorders remains largely unknown. In particular, much effort has been focussed on using in vitro approaches to better understand the cellular and signalling mechanisms of actions of IL-1, yet some discrepancies in the literature regarding the effects produced by IL-1β in in vitro paradigms of injury still exist, particularly as to whether IL-1 exerts neurotoxic or neuroprotective effects. Here we aim to review the cell-specific and concentration-dependent actions of IL-1 in brain cells, to depict the mechanism by which this cytokine induces neurotoxicity or neuroprotection in acute brain injury. © 2008 Elsevier Ltd. All rights reserved.

Original language	English
Pages (from-to)	1-7
Number of pages	6
Journal	Cytokine
Volume	45
Issue number	1
DOIs	https://doi.org/10.1016/j.cyto.2008.10.008
Publication status	Published - Jan 2009

Keywords

Glia
Interleukin-1
Neuro inflammation
Neurones
Signalling

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Cell-specific and concentration-dependent actions of interleukin-1 in acute brain inflammation

Abstract

Keywords

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