Cell surface trafficking of Fas: A rapid mechanism of p53-mediated apoptosis

Martin Bennett; Kirsty Macdonald; Shiu Wan Chan; J. Paul Luzio; Robert Simari; Peter Weissberg

doi:10.1126/science.282.5387.290

Cell surface trafficking of Fas: A rapid mechanism of p53-mediated apoptosis

Martin Bennett, Kirsty Macdonald, Shiu Wan Chan, J. Paul Luzio, Robert Simari, Peter Weissberg

Research output: Contribution to journal › Article › peer-review

Abstract

p53 acts as a tumor suppressor by inducing both growth arrest and apoptosis. p53-induced apoptosis can occur without new RNA synthesis through an unknown mechanism. In human vascular smooth muscle cells, p53 activation transiently increased surface Fas (CD95) expression by transport from the Golgi complex. Golgi disruption blocked both p53-induced surface Fas expression and apoptosis. p53 also induced Fas-FADD binding and transiently sensitized cells to Fas-induced apoptosis. In contrast, lpr and gld fibroblasts were resistant to p53-induced apoptosis. Thus, p53 can mediate apoptosis through Fas transport from cytoplasmic stores.

Original language	English
Pages (from-to)	290-293
Number of pages	3
Journal	Science
Volume	282
Issue number	5387
DOIs	https://doi.org/10.1126/science.282.5387.290
Publication status	Published - 9 Oct 1998

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10.1126/science.282.5387.290

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abstract = "p53 acts as a tumor suppressor by inducing both growth arrest and apoptosis. p53-induced apoptosis can occur without new RNA synthesis through an unknown mechanism. In human vascular smooth muscle cells, p53 activation transiently increased surface Fas (CD95) expression by transport from the Golgi complex. Golgi disruption blocked both p53-induced surface Fas expression and apoptosis. p53 also induced Fas-FADD binding and transiently sensitized cells to Fas-induced apoptosis. In contrast, lpr and gld fibroblasts were resistant to p53-induced apoptosis. Thus, p53 can mediate apoptosis through Fas transport from cytoplasmic stores.",

author = "Martin Bennett and Kirsty Macdonald and Chan, {Shiu Wan} and Luzio, {J. Paul} and Robert Simari and Peter Weissberg",

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AU - Bennett, Martin

AU - Macdonald, Kirsty

AU - Chan, Shiu Wan

AU - Luzio, J. Paul

AU - Simari, Robert

AU - Weissberg, Peter

PY - 1998/10/9

Y1 - 1998/10/9

N2 - p53 acts as a tumor suppressor by inducing both growth arrest and apoptosis. p53-induced apoptosis can occur without new RNA synthesis through an unknown mechanism. In human vascular smooth muscle cells, p53 activation transiently increased surface Fas (CD95) expression by transport from the Golgi complex. Golgi disruption blocked both p53-induced surface Fas expression and apoptosis. p53 also induced Fas-FADD binding and transiently sensitized cells to Fas-induced apoptosis. In contrast, lpr and gld fibroblasts were resistant to p53-induced apoptosis. Thus, p53 can mediate apoptosis through Fas transport from cytoplasmic stores.

AB - p53 acts as a tumor suppressor by inducing both growth arrest and apoptosis. p53-induced apoptosis can occur without new RNA synthesis through an unknown mechanism. In human vascular smooth muscle cells, p53 activation transiently increased surface Fas (CD95) expression by transport from the Golgi complex. Golgi disruption blocked both p53-induced surface Fas expression and apoptosis. p53 also induced Fas-FADD binding and transiently sensitized cells to Fas-induced apoptosis. In contrast, lpr and gld fibroblasts were resistant to p53-induced apoptosis. Thus, p53 can mediate apoptosis through Fas transport from cytoplasmic stores.

U2 - 10.1126/science.282.5387.290

DO - 10.1126/science.282.5387.290

M3 - Article

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VL - 282

SP - 290

EP - 293

JO - Science

JF - Science

IS - 5387

ER -

Cell surface trafficking of Fas: A rapid mechanism of p53-mediated apoptosis

Abstract

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