Cellular automaton model of cell response to targeted radiation.

Karen Kirkby; M Richard; K J Kirkby; R P Webb; N F Kirkby

doi:10.1016/j.apradiso.2008.06.044

Cellular automaton model of cell response to targeted radiation.

Karen Kirkby, M Richard, K J Kirkby, R P Webb, N F Kirkby

Research output: Contribution to journal › Article › peer-review

Abstract

It has been shown that the response of cells to low doses of radiation is not linear and cannot be accurately extrapolated from the high dose response. To investigate possible mechanisms involved in the behaviour of cells under very low doses of radiation, a cellular automaton (CA) model was created. The diffusion and consumption of glucose in the culture dish were computed in parallel to the growth of cells. A new model for calculating survival probability was introduced; the communication between targeted and non-targeted cells was also included. Early results on the response of non-confluent cells to targeted irradiation showed the capability of the model to take account for the non-linear response in the low-dose domain.

Original language	English
Journal	Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine
Volume	67
Issue number	3
DOIs	https://doi.org/10.1016/j.apradiso.2008.06.044
Publication status	Published - Mar 2009

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10.1016/j.apradiso.2008.06.044

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title = "Cellular automaton model of cell response to targeted radiation.",

abstract = "It has been shown that the response of cells to low doses of radiation is not linear and cannot be accurately extrapolated from the high dose response. To investigate possible mechanisms involved in the behaviour of cells under very low doses of radiation, a cellular automaton (CA) model was created. The diffusion and consumption of glucose in the culture dish were computed in parallel to the growth of cells. A new model for calculating survival probability was introduced; the communication between targeted and non-targeted cells was also included. Early results on the response of non-confluent cells to targeted irradiation showed the capability of the model to take account for the non-linear response in the low-dose domain.",

author = "Karen Kirkby and M Richard and Kirkby, {K J} and Webb, {R P} and Kirkby, {N F}",

year = "2009",

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language = "English",

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AU - Kirkby, Karen

AU - Richard, M

AU - Kirkby, K J

AU - Webb, R P

AU - Kirkby, N F

PY - 2009/3

Y1 - 2009/3

N2 - It has been shown that the response of cells to low doses of radiation is not linear and cannot be accurately extrapolated from the high dose response. To investigate possible mechanisms involved in the behaviour of cells under very low doses of radiation, a cellular automaton (CA) model was created. The diffusion and consumption of glucose in the culture dish were computed in parallel to the growth of cells. A new model for calculating survival probability was introduced; the communication between targeted and non-targeted cells was also included. Early results on the response of non-confluent cells to targeted irradiation showed the capability of the model to take account for the non-linear response in the low-dose domain.

AB - It has been shown that the response of cells to low doses of radiation is not linear and cannot be accurately extrapolated from the high dose response. To investigate possible mechanisms involved in the behaviour of cells under very low doses of radiation, a cellular automaton (CA) model was created. The diffusion and consumption of glucose in the culture dish were computed in parallel to the growth of cells. A new model for calculating survival probability was introduced; the communication between targeted and non-targeted cells was also included. Early results on the response of non-confluent cells to targeted irradiation showed the capability of the model to take account for the non-linear response in the low-dose domain.

U2 - 10.1016/j.apradiso.2008.06.044

DO - 10.1016/j.apradiso.2008.06.044

M3 - Article

C2 - 18824365

SN - 1872-9800

VL - 67

JO - Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

JF - Applied radiation and isotopes : including data, instrumentation and methods for use in agriculture, industry and medicine

IS - 3

ER -

Cellular automaton model of cell response to targeted radiation.

Abstract

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