Cerebral acetylcholine esterase activity in mild cognitive impairment

Karl Herholz; Simon Weisenbach; Elke Kalbe; Nico J. Diederich; Wolf Dieter Heiss

doi:10.1097/01.wnr.0000177007.21732.7b

Cerebral acetylcholine esterase activity in mild cognitive impairment

Karl Herholz, Simon Weisenbach, Elke Kalbe, Nico J. Diederich, Wolf Dieter Heiss

Research output: Contribution to journal › Article › peer-review

Abstract

Mild cognitive impairment may be an early clinical manifestation of Alzheimer's disease, but there are also patients who remain stable or remit. In-vivo measurements of cortical acetylcholine esterase activity by positron emission tomography have shown that it is reduced in Alzheimer's disease, and we investigated whether there is also a reduction in mild cognitive impairment. A significant reduction was observed in three of eight patients, and a significant association was found with progression to Alzheimer's disease within 18 months. These results suggest that low cortical acetylcholine esterase activity may be an indicator of impending dementia in patients with mild cognitive impairment. © 2005 Lippincott Williams & Wilkins.

Original language	English
Pages (from-to)	1431-1434
Number of pages	3
Journal	NeuroReport
Volume	16
Issue number	13
DOIs	https://doi.org/10.1097/01.wnr.0000177007.21732.7b
Publication status	Published - 8 Sept 2005

Keywords

Acetylcholine esterase
Alzheimer's disease
Longitudinal study
Mild cognitive impairment (MCI)
Positron emission tomography

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10.1097/01.wnr.0000177007.21732.7b

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title = "Cerebral acetylcholine esterase activity in mild cognitive impairment",

abstract = "Mild cognitive impairment may be an early clinical manifestation of Alzheimer's disease, but there are also patients who remain stable or remit. In-vivo measurements of cortical acetylcholine esterase activity by positron emission tomography have shown that it is reduced in Alzheimer's disease, and we investigated whether there is also a reduction in mild cognitive impairment. A significant reduction was observed in three of eight patients, and a significant association was found with progression to Alzheimer's disease within 18 months. These results suggest that low cortical acetylcholine esterase activity may be an indicator of impending dementia in patients with mild cognitive impairment. {\textcopyright} 2005 Lippincott Williams & Wilkins.",

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AU - Weisenbach, Simon

AU - Kalbe, Elke

AU - Diederich, Nico J.

AU - Heiss, Wolf Dieter

PY - 2005/9/8

Y1 - 2005/9/8

N2 - Mild cognitive impairment may be an early clinical manifestation of Alzheimer's disease, but there are also patients who remain stable or remit. In-vivo measurements of cortical acetylcholine esterase activity by positron emission tomography have shown that it is reduced in Alzheimer's disease, and we investigated whether there is also a reduction in mild cognitive impairment. A significant reduction was observed in three of eight patients, and a significant association was found with progression to Alzheimer's disease within 18 months. These results suggest that low cortical acetylcholine esterase activity may be an indicator of impending dementia in patients with mild cognitive impairment. © 2005 Lippincott Williams & Wilkins.

AB - Mild cognitive impairment may be an early clinical manifestation of Alzheimer's disease, but there are also patients who remain stable or remit. In-vivo measurements of cortical acetylcholine esterase activity by positron emission tomography have shown that it is reduced in Alzheimer's disease, and we investigated whether there is also a reduction in mild cognitive impairment. A significant reduction was observed in three of eight patients, and a significant association was found with progression to Alzheimer's disease within 18 months. These results suggest that low cortical acetylcholine esterase activity may be an indicator of impending dementia in patients with mild cognitive impairment. © 2005 Lippincott Williams & Wilkins.

KW - Acetylcholine esterase

KW - Alzheimer's disease

KW - Longitudinal study

KW - Mild cognitive impairment (MCI)

KW - Positron emission tomography

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EP - 1434

JO - NeuroReport

JF - NeuroReport

IS - 13

ER -

Cerebral acetylcholine esterase activity in mild cognitive impairment

Abstract

Keywords

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