Cerebral metabolic correlates of four dementia scales in Alzheimer's disease

Karl Herholz; E Salmon; S Lespagnard; P Marique; F Peeters; [Unknown] KG; D Perani; V Holthoff; E Kalbe; D Anchisi; S Adam; F Collette; G Garraux

Cerebral metabolic correlates of four dementia scales in Alzheimer's disease

Karl Herholz, E Salmon, S Lespagnard, P Marique, F Peeters, [Unknown] KG, D Perani, V Holthoff, E Kalbe, D Anchisi, S Adam, F Collette, G Garraux

Research output: Contribution to journal › Article › peer-review

Abstract

Department of Neurology, University of Cologne, Koln, Germany. [email protected] cognitive impairment may be an early clinical manifestation of Alzheimer's disease, but there are also patients who remain stable or remit. In-vivo measurements of cortical acetylcholine esterase activity by positron emission tomography have shown that it is reduced in Alzheimer's disease, and we investigated whether there is also a reduction in mild cognitive impairment. A significant reduction was observed in three of eight patients, and a significant association was found with progression to Alzheimer's disease within 18 months. These results suggest that low cortical acetylcholine esterase activity may be an indicator of impending dementia in patients with mild cognitive impairment.PMID: 16110265 [PubMed - indexed for MEDLINE]

Original language	English
Pages (from-to)	283–290
Number of pages	8
Journal	Journal of Neurology
Volume	252
Issue number	3
Publication status	Published - 2005

Cite this

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title = "Cerebral metabolic correlates of four dementia scales in Alzheimer's disease",

abstract = "Department of Neurology, University of Cologne, Koln, Germany. [email protected] cognitive impairment may be an early clinical manifestation of Alzheimer's disease, but there are also patients who remain stable or remit. In-vivo measurements of cortical acetylcholine esterase activity by positron emission tomography have shown that it is reduced in Alzheimer's disease, and we investigated whether there is also a reduction in mild cognitive impairment. A significant reduction was observed in three of eight patients, and a significant association was found with progression to Alzheimer's disease within 18 months. These results suggest that low cortical acetylcholine esterase activity may be an indicator of impending dementia in patients with mild cognitive impairment.PMID: 16110265 [PubMed - indexed for MEDLINE]",

author = "Karl Herholz and E Salmon and S Lespagnard and P Marique and F Peeters and [Unknown] KG and D Perani and V Holthoff and E Kalbe and D Anchisi and S Adam and F Collette and G Garraux",

year = "2005",

language = "English",

volume = "252",

pages = "283–290",

journal = "Journal of Neurology",

issn = "0340-5354",

publisher = "Springer Nature",

number = "3",

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TY - JOUR

T1 - Cerebral metabolic correlates of four dementia scales in Alzheimer's disease

AU - Herholz, Karl

AU - Salmon, E

AU - Lespagnard, S

AU - Marique, P

AU - Peeters, F

AU - KG, [Unknown]

AU - Perani, D

AU - Holthoff, V

AU - Kalbe, E

AU - Anchisi, D

AU - Adam, S

AU - Collette, F

AU - Garraux, G

PY - 2005

Y1 - 2005

N2 - Department of Neurology, University of Cologne, Koln, Germany. [email protected] cognitive impairment may be an early clinical manifestation of Alzheimer's disease, but there are also patients who remain stable or remit. In-vivo measurements of cortical acetylcholine esterase activity by positron emission tomography have shown that it is reduced in Alzheimer's disease, and we investigated whether there is also a reduction in mild cognitive impairment. A significant reduction was observed in three of eight patients, and a significant association was found with progression to Alzheimer's disease within 18 months. These results suggest that low cortical acetylcholine esterase activity may be an indicator of impending dementia in patients with mild cognitive impairment.PMID: 16110265 [PubMed - indexed for MEDLINE]

AB - Department of Neurology, University of Cologne, Koln, Germany. [email protected] cognitive impairment may be an early clinical manifestation of Alzheimer's disease, but there are also patients who remain stable or remit. In-vivo measurements of cortical acetylcholine esterase activity by positron emission tomography have shown that it is reduced in Alzheimer's disease, and we investigated whether there is also a reduction in mild cognitive impairment. A significant reduction was observed in three of eight patients, and a significant association was found with progression to Alzheimer's disease within 18 months. These results suggest that low cortical acetylcholine esterase activity may be an indicator of impending dementia in patients with mild cognitive impairment.PMID: 16110265 [PubMed - indexed for MEDLINE]

M3 - Article

SN - 0340-5354

VL - 252

SP - 283

EP - 290

JO - Journal of Neurology

JF - Journal of Neurology

IS - 3

ER -

Cerebral metabolic correlates of four dementia scales in Alzheimer's disease

Abstract

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