Cerebral metabolic correlates of four dementia scales in Alzheimer's disease

Karl Herholz, E Salmon, S Lespagnard, P Marique, F Peeters, [Unknown] KG, D Perani, V Holthoff, E Kalbe, D Anchisi, S Adam, F Collette, G Garraux

    Research output: Contribution to journalArticlepeer-review


    Department of Neurology, University of Cologne, Koln, Germany. karl.herholz@manchester.ac.ukMild cognitive impairment may be an early clinical manifestation of Alzheimer's disease, but there are also patients who remain stable or remit. In-vivo measurements of cortical acetylcholine esterase activity by positron emission tomography have shown that it is reduced in Alzheimer's disease, and we investigated whether there is also a reduction in mild cognitive impairment. A significant reduction was observed in three of eight patients, and a significant association was found with progression to Alzheimer's disease within 18 months. These results suggest that low cortical acetylcholine esterase activity may be an indicator of impending dementia in patients with mild cognitive impairment.PMID: 16110265 [PubMed - indexed for MEDLINE]
    Original languageEnglish
    Pages (from-to)283–290
    Number of pages8
    JournalJournal of Neurology
    Issue number3
    Publication statusPublished - 2005


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