Cerebral T1p relaxation time increases immediately upon global ischemia in the rat independently of blood glucose and anoxic depolarization

Risto Kauppinen, Mikko I. Kettunen, Olli H J Gröhn, Markku Penttonen, Risto A. Kauppinen

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Time-dependent changes of T1 in the rotating frame (T1p), diffusion, T2, and magnetization transfer contrast on cardiac arrest-induced global ischemia in rat were investigated. T1p, as acquired with spin lock amplitudes >0.6 G, started to increase 10-20 sec after cardiac arrest followed by an increase within 3-4 min to a level that was 6-8% greater than in normal brain. The ischemic T1p response coincided with the drop of water diffusion coefficient in normoglycemic animals. However, unlike the rate of diffusion, the kinetics of T1p were not affected by either preischemic hypoglycemia or hyperglycemia. Similar to diffusion, the kinetics of anoxic depolarization were dependent on preischemic blood glucose levels. Ischemia caused a reduction in the Hahn spin echo T2 as a result of blood oxygenation level-dependent (BOLD) effect; maximal negative BOLD seen by 40 sec. In the animals injected with an ironoxide particle contrast agent, AMI-227, prior to the insult, both T1p and T2 immediately increased in concert on induction of ischemia. In contrast to the T1p and diffusion changes, a much slower change in magnetization transfer contrast was evident over the first 20 min of ischemia. These data demonstrate that T1p immediately increases following ischemia and that the pathophysiological mechanisms affecting this relaxation time may not directly involve magnetization transfer. The mechanisms prolonging T1p differ from those affecting water diffusion with respect to their sensitivities to glucose and are apparently independent of membrane depolarization. © 2001 Wiley-Liss, Inc.
    Original languageEnglish
    Pages (from-to)565-572
    Number of pages7
    JournalMagnetic Resonance in Medicine
    Volume46
    Issue number3
    DOIs
    Publication statusPublished - 2001

    Keywords

    • Brain
    • Diffusion
    • Glucose
    • Ischemia
    • MRI
    • T1p

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