CFTR structure and cystic fibrosis.

Natasha Cant, Naomi Pollock, Robert C Ford

    Research output: Contribution to journalArticlepeer-review

    Abstract

    CFTR (cystic fibrosis transmembrane conductance regulator) is a member of the ATP-binding cassette family of membrane proteins. Although almost all members of this family are transporters, CFTR functions as a channel with specificity for anions, in particular chloride and bicarbonate. In this review we look at what is known about CFTR structure and function within the context of the ATP-binding cassette family. We also review current strategies aimed at obtaining the high resolution structure of the protein.
    Original languageEnglish
    JournalThe international journal of biochemistry & cell biology
    Volume52
    DOIs
    Publication statusPublished - Jul 2014

    Keywords

    • CFTR
    • Cystic fibrosis
    • Ion channel
    • Membrane protein
    • Protein structure

    Fingerprint

    Dive into the research topics of 'CFTR structure and cystic fibrosis.'. Together they form a unique fingerprint.

    Cite this