Challenges and Opportunities for In Vitro–In Vivo Extrapolation of Aldehyde Oxidase-Mediated Clearance: Toward a Roadmap for Quantitative Translation

Nihan Izat; Jayaprakasam Bolleddula; Armina Abbasi; Lionel Cheruzel; Robert S. Jones; Darren Moss; Fatima Ortega-Muro; Yannick Parmentier; Vincent C. Peterkin; Dan-Dan Tian; Karthik Venkatakrishnan; Michael A. Zientek; Jill Barber; J. Brian Houston; Aleksandra Galetin; Daniel Scotcher

doi:10.1124/dmd.123.001436

Challenges and Opportunities for In Vitro–In Vivo Extrapolation of Aldehyde Oxidase-Mediated Clearance: Toward a Roadmap for Quantitative Translation

Nihan Izat
, Jayaprakasam Bolleddula
, Armina Abbasi
, Lionel Cheruzel
, Robert S. Jones
, Darren Moss
, Fatima Ortega-Muro
, Yannick Parmentier
, Vincent C. Peterkin
, Dan-Dan Tian
, Karthik Venkatakrishnan
, Michael A. Zientek
, Jill Barber
, J. Brian Houston
, Aleksandra Galetin
, Daniel Scotcher

Pharmacy

Research output: Contribution to journal › Article › peer-review

Original language	English
Journal	Drug Metabolism and Disposition
DOIs	https://doi.org/10.1124/dmd.123.001436
Publication status	Published - Dec 2023

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10.1124/dmd.123.001436

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Izat, N., Bolleddula, J., Abbasi, A., Cheruzel, L., Jones, R. S., Moss, D., Ortega-Muro, F., Parmentier, Y., Peterkin, V. C., Tian, D.-D., Venkatakrishnan, K., Zientek, M. A., Barber, J., Houston, J. B., Galetin, A., & Scotcher, D. (2023). Challenges and Opportunities for In Vitro–In Vivo Extrapolation of Aldehyde Oxidase-Mediated Clearance: Toward a Roadmap for Quantitative Translation. Drug Metabolism and Disposition. https://doi.org/10.1124/dmd.123.001436

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title = "Challenges and Opportunities for In Vitro{\textendash}In Vivo Extrapolation of Aldehyde Oxidase-Mediated Clearance: Toward a Roadmap for Quantitative Translation",

author = "Nihan Izat and Jayaprakasam Bolleddula and Armina Abbasi and Lionel Cheruzel and Jones, \{Robert S.\} and Darren Moss and Fatima Ortega-Muro and Yannick Parmentier and Peterkin, \{Vincent C.\} and Dan-Dan Tian and Karthik Venkatakrishnan and Zientek, \{Michael A.\} and Jill Barber and Houston, \{J. Brian\} and Aleksandra Galetin and Daniel Scotcher",

year = "2023",

month = dec,

doi = "10.1124/dmd.123.001436",

language = "English",

journal = "Drug Metabolism and Disposition",

issn = "0090-9556",

publisher = "Elsevier BV",

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Izat, N, Bolleddula, J, Abbasi, A, Cheruzel, L, Jones, RS, Moss, D, Ortega-Muro, F, Parmentier, Y, Peterkin, VC, Tian, D-D, Venkatakrishnan, K, Zientek, MA, Barber, J, Houston, JB, Galetin, A & Scotcher, D 2023, 'Challenges and Opportunities for In Vitro–In Vivo Extrapolation of Aldehyde Oxidase-Mediated Clearance: Toward a Roadmap for Quantitative Translation', Drug Metabolism and Disposition. https://doi.org/10.1124/dmd.123.001436

TY - JOUR

T1 - Challenges and Opportunities for In Vitro–In Vivo Extrapolation of Aldehyde Oxidase-Mediated Clearance: Toward a Roadmap for Quantitative Translation

AU - Izat, Nihan

AU - Bolleddula, Jayaprakasam

AU - Abbasi, Armina

AU - Cheruzel, Lionel

AU - Jones, Robert S.

AU - Moss, Darren

AU - Ortega-Muro, Fatima

AU - Parmentier, Yannick

AU - Peterkin, Vincent C.

AU - Tian, Dan-Dan

AU - Venkatakrishnan, Karthik

AU - Zientek, Michael A.

AU - Barber, Jill

AU - Houston, J. Brian

AU - Galetin, Aleksandra

AU - Scotcher, Daniel

PY - 2023/12

Y1 - 2023/12

UR - https://doi.org/10.1124/dmd.123.001436

U2 - 10.1124/dmd.123.001436

DO - 10.1124/dmd.123.001436

M3 - Article

SN - 0090-9556

JO - Drug Metabolism and Disposition

JF - Drug Metabolism and Disposition

ER -

Challenges and Opportunities for In Vitro–In Vivo Extrapolation of Aldehyde Oxidase-Mediated Clearance: Toward a Roadmap for Quantitative Translation

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