Challenges in cell transplantation for muscular dystrophy

Francesco Galli, Vincent Mouly, Gillian Butler-browne, Giulio Cossu

Research output: Contribution to journalArticlepeer-review


For decades now, cell transplantation has been considered a possible therapeutic strategy for muscular dystrophy, but failures have largely outnumbered success or at least encouraging outcomes.

In this review we will briefly recall the history of cell transplantation, discuss the peculiar features of skeletal muscle, and dystrophic skeletal muscle in particular, that make the procedure complicated and inefficient. As there are many recent and exhaustive reviews on the various myogenic cell types that have been or will be transplanted, we will only briefly describe them and refer the reader to these reviews.

Finally, we will discuss possible strategies to overcome the hurdles that prevent biological efficacy and hence clinical success.
Original languageEnglish
Pages (from-to)112908
JournalExperimental Cell Research
Issue number1
Early online date1 Nov 2021
Publication statusPublished - 1 Dec 2021


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