Changes in adrenoreceptor density in brown adipose tissue from hyperthyroid rats

Nancy J. Rothwell, Michael J. Stock, Deepak K. Sudera

Research output: Contribution to journalArticlepeer-review

Abstract

Treatment of rats with triiodothyronine (T3 10 μg/100 g per day, 20 days) increased the mass of brown adipose tissue (BAT) and heart ventricle and stimulated β-adrenoreceptor number (assessed from radioligand binding) by 43% in isolated BAT and heart membranes. α-Receptors number was slightly increased in BAT membranes (42%) but reduced in heart from T3-treated rats. The ratio of α-receptors/β-receptors was unaffected by T3 treatment in BAT membranes (control and hyperthyroid = 1.54) but reduced in heart (control = 2.8, T3 = 1.04). © 1985.
Original languageEnglish
Pages (from-to)227-229
Number of pages2
JournalEuropean journal of pharmacology
Volume114
Issue number2
Publication statusPublished - 15 Aug 1985

Keywords

  • α-Adrenoreceptors
  • β-Adrenoceptors
  • Brown adipose tissue
  • Heart
  • Triiodothyronine

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