Changes in brain morphology in patients with obstructive sleep apnoea

M. J. Morrell, M. L. Jackson, G. L. Twigg, R. Ghiassi, D. W. McRobbie, R. A. Quest, H. Pardoe, G. S. Pell, D. F. Abbott, P. D. Rochford, G. D. Jackson, R. J. Pierce, F. J. O'Donoghue, D. R. Corfield

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Background: Obstructive sleep apnoea (OSA) is a common disease that leads to daytime sleepiness and cognitive impairment. Attempts to investigate changes in brain morphology that may underlie these impairments have led to conflicting conclusions. This study was undertaken to aim to resolve this confusion, and determine whether OSA is associated with changes in brain morphology in a large group of patients with OSA, using improved voxel-based morphometry analysis, an automated unbiased method of detecting local changes in brain structure. Methods: 60 patients with OSA (mean apnoea hypopnoea index 55 (95% CI 48 to 62) events/h, 3 women) and 60 non-apnoeic controls (mean apnoea hypopnoea index 4 (95% CI 3 to 5) events/h, 5 women) were studied. Subjects were imaged using T1-weighted 3-D structural MRI (69 subjects at 1.5 T, 51 subjects at 3 T). Differences in grey matter were investigated in the two groups, controlling for age, sex, site and intracranial volume. Dedicated cerebellar analysis was performed on a subset of 108 scans using a spatially unbiased infratentorial template. Results: Patients with OSA had a reduction in grey matter volume in the right middle temporal gyrus compared with non-apnoeic controls (p
    Original languageEnglish
    Pages (from-to)908-914
    Number of pages6
    JournalThorax
    Volume65
    Issue number10
    DOIs
    Publication statusPublished - Oct 2010

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