Changes in exhaled breath condensate pH in healthy and asthmatic pregnant women

N. Eszes; A. Bikov; Z. Lázár; A. Bohács; V. Müller; B. Stenczer; J. Rigõ Jr.; G. Losonczy; I. Horváth; L. Tamási

doi:10.1111/aogs.12094

Changes in exhaled breath condensate pH in healthy and asthmatic pregnant women

N. Eszes, A. Bikov, Z. Lázár, A. Bohács, V. Müller, B. Stenczer, J. Rigõ Jr., G. Losonczy, I. Horváth, L. Tamási

Division of Immunology, Immunity to Infection and Respiratory Medicine

Research output: Contribution to journal › Article › peer-review

Abstract

Objective Asthma is a common chronic disease complicating pregnancy with a risk for perinatal complications. Control of airway inflammation in the asthmatic pregnancy improves pregnancy outcomes. Our aim was to evaluate pH of exhaled breath condensate (EBC), a non-invasive method for the assessment of asthmatic airway inflammation, in healthy and asthmatic pregnancies. Design Cross-sectional study. Setting Hungarian university clinics. Population Seventeen healthy pregnant women, 21 asthmatic pregnant women, 23 healthy non-pregnant women and 22 asthmatic non-pregnant women. Methods EBC samples were collected using a portable condenser, EBC pH was measured after argon deaeration. Main outcome measure EBC pH. Results EBC pH (mean ± SD) of healthy non-pregnant and asthmatic non-pregnant women was similar (7.75 ± 0.27 vs. 7.54 ± 0.57; p = 0.118), probably indicating an optimal control of airway inflammation in asthmatic women. On the other hand, EBC pH was higher in healthy pregnant women compared with healthy non-pregnant women (8.02 ± 0.43 vs. 7.75 ± 0.27; p = 0.017). Higher EBC pH accompanying healthy pregnancy was absent in asthmatic pregnant patients whose EBC pH was lower (7.65 ± 0.38) than that of healthy pregnant women (p = 0.006), and it was similar to that in asthmatic and healthy non-pregnant women (p = 0.470 and p = 0.300, respectively). The EBC pH in asthmatic pregnant women correlated positively with birthweight (r = 0.49, p = 0.047) and negatively with forced vital capacity (r = 0.45, p = 0.039). EBC pH was not related to blood pH. Conclusions EBC pH is higher in healthy pregnant women but not in asthmatic pregnant women compared with data from healthy non-pregnant women, indicating that oxidative inflammatory processes induced by asthma may compromise the regulatory mechanisms causing alkaline pH in the airways during pregnancy. © 2013 The Authors Acta Obstetricia et Gynecologica Scandinavica © 2013 Nordic Federation of Societies of Obstetrics and Gynecology.

Original language	English
Pages (from-to)	591-597
Number of pages	7
Journal	Acta Obstetricia et Gynecologica Scandinavica
Volume	92
Issue number	5
DOIs	https://doi.org/10.1111/aogs.12094
Publication status	Published - 2013

Keywords

Airway inflammation
asthmatic pregnancy
exhaled breath condensate pH
healthy pregnancy
neonatal birthweight
argon
adult
aeration
article
asthma
birth weight
blood pH
clinical article
controlled study
cross-sectional study
disease control
exhaled breath condensate
expired air
female
forced vital capacity
human
medical assessment
non invasive procedure
outcome assessment
pH
pH measurement
pregnant woman
priority journal
respiratory tract inflammation
Adult
Asthma
Birth Weight
Breath Tests
Case-Control Studies
Cross-Sectional Studies
Exhalation
Female
Humans
Hydrogen-Ion Concentration
Inflammation
Pregnancy
Pregnancy Complications
Vital Capacity
Young Adult

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1111/aogs.12094

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Cite this

@article{0bf775d0cd314063b229c19cb55eb27b,

title = "Changes in exhaled breath condensate pH in healthy and asthmatic pregnant women",

abstract = "Objective Asthma is a common chronic disease complicating pregnancy with a risk for perinatal complications. Control of airway inflammation in the asthmatic pregnancy improves pregnancy outcomes. Our aim was to evaluate pH of exhaled breath condensate (EBC), a non-invasive method for the assessment of asthmatic airway inflammation, in healthy and asthmatic pregnancies. Design Cross-sectional study. Setting Hungarian university clinics. Population Seventeen healthy pregnant women, 21 asthmatic pregnant women, 23 healthy non-pregnant women and 22 asthmatic non-pregnant women. Methods EBC samples were collected using a portable condenser, EBC pH was measured after argon deaeration. Main outcome measure EBC pH. Results EBC pH (mean ± SD) of healthy non-pregnant and asthmatic non-pregnant women was similar (7.75 ± 0.27 vs. 7.54 ± 0.57; p = 0.118), probably indicating an optimal control of airway inflammation in asthmatic women. On the other hand, EBC pH was higher in healthy pregnant women compared with healthy non-pregnant women (8.02 ± 0.43 vs. 7.75 ± 0.27; p = 0.017). Higher EBC pH accompanying healthy pregnancy was absent in asthmatic pregnant patients whose EBC pH was lower (7.65 ± 0.38) than that of healthy pregnant women (p = 0.006), and it was similar to that in asthmatic and healthy non-pregnant women (p = 0.470 and p = 0.300, respectively). The EBC pH in asthmatic pregnant women correlated positively with birthweight (r = 0.49, p = 0.047) and negatively with forced vital capacity (r = 0.45, p = 0.039). EBC pH was not related to blood pH. Conclusions EBC pH is higher in healthy pregnant women but not in asthmatic pregnant women compared with data from healthy non-pregnant women, indicating that oxidative inflammatory processes induced by asthma may compromise the regulatory mechanisms causing alkaline pH in the airways during pregnancy. {\textcopyright} 2013 The Authors Acta Obstetricia et Gynecologica Scandinavica {\textcopyright} 2013 Nordic Federation of Societies of Obstetrics and Gynecology.",

keywords = "Airway inflammation, asthmatic pregnancy, exhaled breath condensate pH, healthy pregnancy, neonatal birthweight, argon, adult, aeration, article, asthma, birth weight, blood pH, clinical article, controlled study, cross-sectional study, disease control, exhaled breath condensate, expired air, female, forced vital capacity, human, medical assessment, non invasive procedure, outcome assessment, pH, pH measurement, pregnant woman, priority journal, respiratory tract inflammation, Adult, Asthma, Birth Weight, Breath Tests, Case-Control Studies, Cross-Sectional Studies, Exhalation, Female, Humans, Hydrogen-Ion Concentration, Inflammation, Pregnancy, Pregnancy Complications, Vital Capacity, Young Adult",

author = "N. Eszes and A. Bikov and Z. L{\'a}z{\'a}r and A. Boh{\'a}cs and V. M{\"u}ller and B. Stenczer and \{Rig{\~o} Jr.\}, J. and G. Losonczy and I. Horv{\'a}th and L. Tam{\'a}si",

note = "Cited By :3 Export Date: 20 February 2019 CODEN: AOGSA Correspondence Address: Horv{\'a}th, I.; Department of Pulmonology, Semmelweis University, Di{\~o}s {\'a}rok 1/C, 1125 Budapest, Hungary; email: [email protected] Chemicals/CAS: argon, 7440-37-1 References: Global Initiative for Asthma, , www.ginasthma.org, Available online at (accessed on May 17, 2011); Murphy, V.E., Gibson, P.G., Asthma in pregnancy (2011) Clin Chest Med, 32, pp. 93-110; Breton, M.C., Beauchesne, M.F., Lemiere, C., Rey, {\'E}., Forget, A., Blais, L., Risk of perinatal mortality associated with asthma during pregnancy (2009) Thorax, 64, pp. 101-106; Maselli, D.J., Adams, S.G., Peters, J.I., Levine, S.M., Management of asthma during pregnancy (2012) Ther Adv Respir Dis, , Nov 5;doi: 10.1177/1753465812464287. Epub ahead of print; Tamasi, L., Horvath, I., Bohacs, A., Muller, V., Losonczy, G., Schatz, M., Asthma in pregnancy - Immunological changes and clinical management (2011) Respir Med, 105, pp. 159-164; Schatz, M., Dombrowski, M.P., Wise, R., Lai, Y., Landon, M., Newman, R.B., The relationship of asthma-specific quality of life during pregnancy to subsequent asthma and perinatal morbidity (2010) J Asthma, 47, pp. 46-50; Elston, W.J., Whittaker, A.J., Khan, L.N., Flood-Page, P., Ramsay, C., Jeffery, P.K., Safety of research bronchoscopy, biopsy and bronchoalveolar lavage in asthma (2004) Eur Respir J, 24, pp. 375-377; Fahy, J.V., Boushey, H.A., Lazarus, S.C., Mauger, E.A., Cherniack, R.M., Chinchilli, V.M., Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter study (2001) Am J Respir Crit Care Med, 163, pp. 1470-1475; Tamasi, L., Bohacs, A., Bikov, A., Andorka, C., Rig{\~o}, Jr.J., Losonczy, G., Exhaled nitric oxide in pregnant healthy and asthmatic women (2009) J Asthma, 46, pp. 786-791; Horvath, I., Hunt, J., Barnes, P.J., Exhaled breath condensate: Methodological recommendations and unresolved questions (2005) Eur Respir J, 26, pp. 523-548. , On behalf of the ATS/ERS Task Force on Exhaled Breath Condensate; Bikov, A., Antus, B., Losonczy, G., Horvath, I., Exhaled breath condensate pH (2010) Eur Resp Soc Monogr, 49, pp. 173-182; Vaughan, J., Ngamtrakulpanit, L., Pajewski, T.N., Turner, R., Nguyen, T.A., Smith, A., Exhaled breath condensate pH is a robust and reproducible assay of airway acidity (2003) Eur Respir J, 22, pp. 889-894; Hunt, J.F., Fang, K., Malik, R., Snyder, A., Malhotra, N., Platts-Mills, T.A., Endogenous airway acidification. Implications for asthma pathophysiology (2000) Am J Respir Crit Care Med, 161, pp. 694-699; Kostikas, K., Papaioannou, A.I., Tanou, K., Giouleka, P., Koutsokera, A., Minas, M., Exhaled NO and exhaled breath condensate pH in the evaluation of asthma control (2011) Respir Med, 105, pp. 526-532; Liu, L., Urban, P., Hunt, J.F., Wilkinson, P., Laning, K., Gaston, B., Changes in exhaled nitric oxide and breath pH during fluticasone wean in asthma (2010) Respiration, 79, pp. 193-199; Rosene-Montella, K., Bourjeily, G., (2009) Pulmonary Problems in Pregnancy, pp. 253-284. , Venous thromboembolism in pregnancy. Bourjeily G. Rosene-Montella K. (eds). New York: Respir Med, Humana Press, a part of Springer Science+Business Media, LLC; George, E.M., Granger, J.P., Recent insights into the pathophysiology of preeclampsia (2010) Expert Rev Obstet Gynecol, 5, pp. 557-566; Stolarek, R., Szkudlarek, U., Luczynska, M., Kasielski, M., Ciesla, W., Lewinski, A., Decreased H2O2 in exhaled breath condensate during pregnancy-feasible effect of 17beta-estradiol (2008) Respir Physiol Neurobiol, 162, pp. 152-159; Lazarus, J.H., Thyroid function in pregnancy (2011) Br Med Bull, 97, pp. 137-148; ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005 (2005) Am J Respir Crit Care Med, 171, pp. 912-930. , American Thoracic Society; European Respiratory Society; Miller, M.R., Hankinson, J., Brusasco, V., Burgos, F., Casaburi, R., Coates, A., Standardisation of spirometry (2005) Eur Respir J, 26, pp. 319-338; Faul, F., Erdfelder, E., Lang, A.-G., Buchner, A., G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences (2007) Behav Res Meth, 39, pp. 175-191; Bohacs, A., Cseh, A., Stenczer, B., M{\"u}ller, V., G{\'a}lffy, G., Molvarec, A., Effector and regulatory lymphocytes in asthmatic pregnant women (2010) Am J Reprod Immunol, 64, pp. 393-401; Ojoo, J.C., Mulrennan, S.A., Kastelik, J.A., Morice, A., Redington, A., Exhaled breath condensate pH and exhaled nitric oxide in allergic asthma and in cystic fibrosis (2005) Thorax, 60, pp. 22-26; Koczulla, R., Dragonieri, S., Schot, R., Bals, R., Gauw, S.A., Vogelmeier, C., Comparison of exhaled breath condensate pH using two commercially available devices in healthy controls, asthma and COPD patients (2009) Respir Res, 10, p. 78; Liu, L., Teague, W.G., Erzurum, S., Fitzpatrick, A., Mantri, S., Dweik, R.A., Determinants of exhaled breath condensate pH in a large population with asthma (2011) Chest, 139, pp. 328-336; Tamasi, L., Bohacs, A., Pallinger, E., Falus, A., Rig{\~o}, Jr.J., M{\"u}ller, V., Increased interferon-gamma- and interleukin-4-synthesizing subsets of circulating T lymphocytes in pregnant asthmatics (2005) Clin Exp Allergy, 35, pp. 1197-1203; Powell, H., Murphy, V.E., Taylor, D.R., Hensley, M.J., McCaffery, K., Giles, W., Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: A double-blind, randomised controlled trial (2011) Lancet, 378 (9795), pp. 983-990; Dressel, H., M{\"u}ller, F., Fischer, R., R{\"o}mmelt, H., Hohlfeld, J.M., Behr, J., Independent information of nonspecific biomarkers in exhaled breath condensate (2010) Respiration, 80, pp. 401-409; Cruz, M.J., S{\'a}nchez-Vidaurre, S., Romero, P.V., Morell, F., Mu{\~n}oz, X., Impact of age on pH, 8-isoprostane, and nitrogen oxides in exhaled breath condensate (2009) Chest, 135, pp. 462-467",

year = "2013",

doi = "10.1111/aogs.12094",

language = "English",

volume = "92",

pages = "591--597",

journal = "Acta Obstetricia et Gynecologica Scandinavica",

issn = "0001-6349",

publisher = "John Wiley \& Sons Ltd",

number = "5",

}

TY - JOUR

T1 - Changes in exhaled breath condensate pH in healthy and asthmatic pregnant women

AU - Eszes, N.

AU - Bikov, A.

AU - Lázár, Z.

AU - Bohács, A.

AU - Müller, V.

AU - Stenczer, B.

AU - Rigõ Jr., J.

AU - Losonczy, G.

AU - Horváth, I.

AU - Tamási, L.

N1 - Cited By :3 Export Date: 20 February 2019 CODEN: AOGSA Correspondence Address: Horváth, I.; Department of Pulmonology, Semmelweis University, Diõs árok 1/C, 1125 Budapest, Hungary; email: [email protected] Chemicals/CAS: argon, 7440-37-1 References: Global Initiative for Asthma, , www.ginasthma.org, Available online at (accessed on May 17, 2011); Murphy, V.E., Gibson, P.G., Asthma in pregnancy (2011) Clin Chest Med, 32, pp. 93-110; Breton, M.C., Beauchesne, M.F., Lemiere, C., Rey, É., Forget, A., Blais, L., Risk of perinatal mortality associated with asthma during pregnancy (2009) Thorax, 64, pp. 101-106; Maselli, D.J., Adams, S.G., Peters, J.I., Levine, S.M., Management of asthma during pregnancy (2012) Ther Adv Respir Dis, , Nov 5;doi: 10.1177/1753465812464287. Epub ahead of print; Tamasi, L., Horvath, I., Bohacs, A., Muller, V., Losonczy, G., Schatz, M., Asthma in pregnancy - Immunological changes and clinical management (2011) Respir Med, 105, pp. 159-164; Schatz, M., Dombrowski, M.P., Wise, R., Lai, Y., Landon, M., Newman, R.B., The relationship of asthma-specific quality of life during pregnancy to subsequent asthma and perinatal morbidity (2010) J Asthma, 47, pp. 46-50; Elston, W.J., Whittaker, A.J., Khan, L.N., Flood-Page, P., Ramsay, C., Jeffery, P.K., Safety of research bronchoscopy, biopsy and bronchoalveolar lavage in asthma (2004) Eur Respir J, 24, pp. 375-377; Fahy, J.V., Boushey, H.A., Lazarus, S.C., Mauger, E.A., Cherniack, R.M., Chinchilli, V.M., Safety and reproducibility of sputum induction in asthmatic subjects in a multicenter study (2001) Am J Respir Crit Care Med, 163, pp. 1470-1475; Tamasi, L., Bohacs, A., Bikov, A., Andorka, C., Rigõ, Jr.J., Losonczy, G., Exhaled nitric oxide in pregnant healthy and asthmatic women (2009) J Asthma, 46, pp. 786-791; Horvath, I., Hunt, J., Barnes, P.J., Exhaled breath condensate: Methodological recommendations and unresolved questions (2005) Eur Respir J, 26, pp. 523-548. , On behalf of the ATS/ERS Task Force on Exhaled Breath Condensate; Bikov, A., Antus, B., Losonczy, G., Horvath, I., Exhaled breath condensate pH (2010) Eur Resp Soc Monogr, 49, pp. 173-182; Vaughan, J., Ngamtrakulpanit, L., Pajewski, T.N., Turner, R., Nguyen, T.A., Smith, A., Exhaled breath condensate pH is a robust and reproducible assay of airway acidity (2003) Eur Respir J, 22, pp. 889-894; Hunt, J.F., Fang, K., Malik, R., Snyder, A., Malhotra, N., Platts-Mills, T.A., Endogenous airway acidification. Implications for asthma pathophysiology (2000) Am J Respir Crit Care Med, 161, pp. 694-699; Kostikas, K., Papaioannou, A.I., Tanou, K., Giouleka, P., Koutsokera, A., Minas, M., Exhaled NO and exhaled breath condensate pH in the evaluation of asthma control (2011) Respir Med, 105, pp. 526-532; Liu, L., Urban, P., Hunt, J.F., Wilkinson, P., Laning, K., Gaston, B., Changes in exhaled nitric oxide and breath pH during fluticasone wean in asthma (2010) Respiration, 79, pp. 193-199; Rosene-Montella, K., Bourjeily, G., (2009) Pulmonary Problems in Pregnancy, pp. 253-284. , Venous thromboembolism in pregnancy. Bourjeily G. Rosene-Montella K. (eds). New York: Respir Med, Humana Press, a part of Springer Science+Business Media, LLC; George, E.M., Granger, J.P., Recent insights into the pathophysiology of preeclampsia (2010) Expert Rev Obstet Gynecol, 5, pp. 557-566; Stolarek, R., Szkudlarek, U., Luczynska, M., Kasielski, M., Ciesla, W., Lewinski, A., Decreased H2O2 in exhaled breath condensate during pregnancy-feasible effect of 17beta-estradiol (2008) Respir Physiol Neurobiol, 162, pp. 152-159; Lazarus, J.H., Thyroid function in pregnancy (2011) Br Med Bull, 97, pp. 137-148; ATS/ERS recommendations for standardized procedures for the online and offline measurement of exhaled lower respiratory nitric oxide and nasal nitric oxide, 2005 (2005) Am J Respir Crit Care Med, 171, pp. 912-930. , American Thoracic Society; European Respiratory Society; Miller, M.R., Hankinson, J., Brusasco, V., Burgos, F., Casaburi, R., Coates, A., Standardisation of spirometry (2005) Eur Respir J, 26, pp. 319-338; Faul, F., Erdfelder, E., Lang, A.-G., Buchner, A., G*Power 3: A flexible statistical power analysis program for the social, behavioral, and biomedical sciences (2007) Behav Res Meth, 39, pp. 175-191; Bohacs, A., Cseh, A., Stenczer, B., Müller, V., Gálffy, G., Molvarec, A., Effector and regulatory lymphocytes in asthmatic pregnant women (2010) Am J Reprod Immunol, 64, pp. 393-401; Ojoo, J.C., Mulrennan, S.A., Kastelik, J.A., Morice, A., Redington, A., Exhaled breath condensate pH and exhaled nitric oxide in allergic asthma and in cystic fibrosis (2005) Thorax, 60, pp. 22-26; Koczulla, R., Dragonieri, S., Schot, R., Bals, R., Gauw, S.A., Vogelmeier, C., Comparison of exhaled breath condensate pH using two commercially available devices in healthy controls, asthma and COPD patients (2009) Respir Res, 10, p. 78; Liu, L., Teague, W.G., Erzurum, S., Fitzpatrick, A., Mantri, S., Dweik, R.A., Determinants of exhaled breath condensate pH in a large population with asthma (2011) Chest, 139, pp. 328-336; Tamasi, L., Bohacs, A., Pallinger, E., Falus, A., Rigõ, Jr.J., Müller, V., Increased interferon-gamma- and interleukin-4-synthesizing subsets of circulating T lymphocytes in pregnant asthmatics (2005) Clin Exp Allergy, 35, pp. 1197-1203; Powell, H., Murphy, V.E., Taylor, D.R., Hensley, M.J., McCaffery, K., Giles, W., Management of asthma in pregnancy guided by measurement of fraction of exhaled nitric oxide: A double-blind, randomised controlled trial (2011) Lancet, 378 (9795), pp. 983-990; Dressel, H., Müller, F., Fischer, R., Römmelt, H., Hohlfeld, J.M., Behr, J., Independent information of nonspecific biomarkers in exhaled breath condensate (2010) Respiration, 80, pp. 401-409; Cruz, M.J., Sánchez-Vidaurre, S., Romero, P.V., Morell, F., Muñoz, X., Impact of age on pH, 8-isoprostane, and nitrogen oxides in exhaled breath condensate (2009) Chest, 135, pp. 462-467

PY - 2013

Y1 - 2013

N2 - Objective Asthma is a common chronic disease complicating pregnancy with a risk for perinatal complications. Control of airway inflammation in the asthmatic pregnancy improves pregnancy outcomes. Our aim was to evaluate pH of exhaled breath condensate (EBC), a non-invasive method for the assessment of asthmatic airway inflammation, in healthy and asthmatic pregnancies. Design Cross-sectional study. Setting Hungarian university clinics. Population Seventeen healthy pregnant women, 21 asthmatic pregnant women, 23 healthy non-pregnant women and 22 asthmatic non-pregnant women. Methods EBC samples were collected using a portable condenser, EBC pH was measured after argon deaeration. Main outcome measure EBC pH. Results EBC pH (mean ± SD) of healthy non-pregnant and asthmatic non-pregnant women was similar (7.75 ± 0.27 vs. 7.54 ± 0.57; p = 0.118), probably indicating an optimal control of airway inflammation in asthmatic women. On the other hand, EBC pH was higher in healthy pregnant women compared with healthy non-pregnant women (8.02 ± 0.43 vs. 7.75 ± 0.27; p = 0.017). Higher EBC pH accompanying healthy pregnancy was absent in asthmatic pregnant patients whose EBC pH was lower (7.65 ± 0.38) than that of healthy pregnant women (p = 0.006), and it was similar to that in asthmatic and healthy non-pregnant women (p = 0.470 and p = 0.300, respectively). The EBC pH in asthmatic pregnant women correlated positively with birthweight (r = 0.49, p = 0.047) and negatively with forced vital capacity (r = 0.45, p = 0.039). EBC pH was not related to blood pH. Conclusions EBC pH is higher in healthy pregnant women but not in asthmatic pregnant women compared with data from healthy non-pregnant women, indicating that oxidative inflammatory processes induced by asthma may compromise the regulatory mechanisms causing alkaline pH in the airways during pregnancy. © 2013 The Authors Acta Obstetricia et Gynecologica Scandinavica © 2013 Nordic Federation of Societies of Obstetrics and Gynecology.

AB - Objective Asthma is a common chronic disease complicating pregnancy with a risk for perinatal complications. Control of airway inflammation in the asthmatic pregnancy improves pregnancy outcomes. Our aim was to evaluate pH of exhaled breath condensate (EBC), a non-invasive method for the assessment of asthmatic airway inflammation, in healthy and asthmatic pregnancies. Design Cross-sectional study. Setting Hungarian university clinics. Population Seventeen healthy pregnant women, 21 asthmatic pregnant women, 23 healthy non-pregnant women and 22 asthmatic non-pregnant women. Methods EBC samples were collected using a portable condenser, EBC pH was measured after argon deaeration. Main outcome measure EBC pH. Results EBC pH (mean ± SD) of healthy non-pregnant and asthmatic non-pregnant women was similar (7.75 ± 0.27 vs. 7.54 ± 0.57; p = 0.118), probably indicating an optimal control of airway inflammation in asthmatic women. On the other hand, EBC pH was higher in healthy pregnant women compared with healthy non-pregnant women (8.02 ± 0.43 vs. 7.75 ± 0.27; p = 0.017). Higher EBC pH accompanying healthy pregnancy was absent in asthmatic pregnant patients whose EBC pH was lower (7.65 ± 0.38) than that of healthy pregnant women (p = 0.006), and it was similar to that in asthmatic and healthy non-pregnant women (p = 0.470 and p = 0.300, respectively). The EBC pH in asthmatic pregnant women correlated positively with birthweight (r = 0.49, p = 0.047) and negatively with forced vital capacity (r = 0.45, p = 0.039). EBC pH was not related to blood pH. Conclusions EBC pH is higher in healthy pregnant women but not in asthmatic pregnant women compared with data from healthy non-pregnant women, indicating that oxidative inflammatory processes induced by asthma may compromise the regulatory mechanisms causing alkaline pH in the airways during pregnancy. © 2013 The Authors Acta Obstetricia et Gynecologica Scandinavica © 2013 Nordic Federation of Societies of Obstetrics and Gynecology.

KW - Airway inflammation

KW - asthmatic pregnancy

KW - exhaled breath condensate pH

KW - healthy pregnancy

KW - neonatal birthweight

KW - argon

KW - adult

KW - aeration

KW - article

KW - asthma

KW - birth weight

KW - blood pH

KW - clinical article

KW - controlled study

KW - cross-sectional study

KW - disease control

KW - exhaled breath condensate

KW - expired air

KW - female

KW - forced vital capacity

KW - human

KW - medical assessment

KW - non invasive procedure

KW - outcome assessment

KW - pH

KW - pH measurement

KW - pregnant woman

KW - priority journal

KW - respiratory tract inflammation

KW - Adult

KW - Asthma

KW - Birth Weight

KW - Breath Tests

KW - Case-Control Studies

KW - Cross-Sectional Studies

KW - Exhalation

KW - Female

KW - Humans

KW - Hydrogen-Ion Concentration

KW - Inflammation

KW - Pregnancy

KW - Pregnancy Complications

KW - Vital Capacity

KW - Young Adult

U2 - 10.1111/aogs.12094

DO - 10.1111/aogs.12094

M3 - Article

SN - 0001-6349

VL - 92

SP - 591

EP - 597

JO - Acta Obstetricia et Gynecologica Scandinavica

JF - Acta Obstetricia et Gynecologica Scandinavica

IS - 5

ER -

Changes in exhaled breath condensate pH in healthy and asthmatic pregnant women

Abstract

Keywords

UN SDGs

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