Changes in quality of life in the first 5 years of disease in a multicenter cohort of patients with systemic lupus erythematosus

M. Urowitz, D. D. Gladman, D. Ibañez, J. Sanchez-Guerrero, S. C. Bae, C. Gordon, P. R. Fortin, A. Clarke, S. Bernatsky, J. G. Hanly, D. J. Wallace, D. Isenberg, A. Rahman, J. Merrill, E. Ginzler, G. S. Alarcõn, B. Fessler, M. Khamashta, K. Steinsson, M. PetriM. Dooley, I. N. Bruce, S. Manzi, G. Sturfelt, O. Nived, R. Ramsey-Goldman, A. Zoma, P. Maddison, K. Kalunian, R. Van Vollenhoven, C. Aranow, J. Romero Diaz, T. Stoll

    Research output: Contribution to journalArticlepeer-review


    Objective. The Medical Outcomes Study Short Form 36 (SF-36) is recommended to assess quality of life (QOL) in systemic lupus erythematosus (SLE). The aim of the current study was to assess QOL over time in the first 5 years of a multicenter inception cohort of patients with SLE. Methods. An inception SLE cohort was assembled according to a standardized protocol between 2000 and 2012. In addition to clinical and laboratory assessments, patients completed the SF-36 at yearly intervals. Only patients who had ≥5 completed QOL questionnaires were included in these analyses. Generalized estimating equation models were run separately for each of the 8 subscales and for the physical and mental component summary scores, adjusting for repeated measures by patients. Results. A total of 495 patients were included. The mean ± SD disease duration at the first visit was 5.3 ± 4.1 months. The mean ± SD age at enrollment was 35.8 ± 13.2 years. All 8 subscales and the 2 summary scores showed improvement in the first 2 years from enrollment. Between years 2 and 5, none of the subscales or summary scores showed any change. Minimum clinically important improvement was achieved by 35-56% of the patients and was influenced by demographic and disease factors. Conclusion. Unlike late-stage lupus, where QOL is stable over time, in patients with early disease, all subscales improve in early followup up to 2 years. Therefore, the SF-36 may be a sensitive outcome measure in early disease in patients with SLE. Copyright © 2014 by the American College of Rheumatology.
    Original languageEnglish
    Pages (from-to)1374-1379
    Number of pages5
    JournalArthritis Care & Research
    Issue number9
    Publication statusPublished - 2014


    • Lupus
    • change over 5 years
    • quality of life


    Dive into the research topics of 'Changes in quality of life in the first 5 years of disease in a multicenter cohort of patients with systemic lupus erythematosus'. Together they form a unique fingerprint.

    Cite this