Changes in sleep-wake cycle after chronic exposure to uranium in rats

Philippe Lestaevel; Cyrill Bussy; François Paquet; Bernadette Dhieux; Didier Clarençon; Pascale Houpert; Patrick Gourmelon

doi:10.1016/j.ntt.2005.07.005

Changes in sleep-wake cycle after chronic exposure to uranium in rats

Philippe Lestaevel, Cyrill Bussy, François Paquet, Bernadette Dhieux, Didier Clarençon, Pascale Houpert, Patrick Gourmelon

Research output: Contribution to journal › Article › peer-review

Abstract

Uranium is a heavy metal known to induce toxicity in kidneys. It is also known to enter the central nervous system, thus inducing neurophysiological effects, after exposure to relatively high concentrations. The effect of chronic uranium exposure (40 mg l- 1 in drinking water, for 90 days) on electroencephalographic architecture has been studied on freely moving rats using a telemetry technique. The main effects of uranium on the sleep-wake cycle were an increase in rapid eye movement sleep (REM-sleep) and theta band power during the light period, as early as Day 30 after exposure commenced. The most probable explanation for these effects is that uranium directly affects the brain. This increase in REM-sleep was previously described in human depression or models of chronically stressed rats and it may be assimilated with some protective or compensatory mechanisms. © 2005 Elsevier Inc. All rights reserved.

Original language	English
Pages (from-to)	835-840
Number of pages	5
Journal	Neurotoxicology and Teratology
Volume	27
Issue number	6
DOIs	https://doi.org/10.1016/j.ntt.2005.07.005
Publication status	Published - Nov 2005

Keywords

Chronic exposure
Depression
EEG
Rapid eye movement sleep
Uranium

Access to Document

10.1016/j.ntt.2005.07.005

Cite this

@article{6eda52e5f58245c5b5e68042f879013e,

title = "Changes in sleep-wake cycle after chronic exposure to uranium in rats",

abstract = "Uranium is a heavy metal known to induce toxicity in kidneys. It is also known to enter the central nervous system, thus inducing neurophysiological effects, after exposure to relatively high concentrations. The effect of chronic uranium exposure (40 mg l- 1 in drinking water, for 90 days) on electroencephalographic architecture has been studied on freely moving rats using a telemetry technique. The main effects of uranium on the sleep-wake cycle were an increase in rapid eye movement sleep (REM-sleep) and theta band power during the light period, as early as Day 30 after exposure commenced. The most probable explanation for these effects is that uranium directly affects the brain. This increase in REM-sleep was previously described in human depression or models of chronically stressed rats and it may be assimilated with some protective or compensatory mechanisms. {\textcopyright} 2005 Elsevier Inc. All rights reserved.",

keywords = "Chronic exposure, Depression, EEG, Rapid eye movement sleep, Uranium",

author = "Philippe Lestaevel and Cyrill Bussy and Fran{\c c}ois Paquet and Bernadette Dhieux and Didier Claren{\c c}on and Pascale Houpert and Patrick Gourmelon",

note = "990TZ Times Cited:19 Cited References Count:23",

year = "2005",

month = nov,

doi = "10.1016/j.ntt.2005.07.005",

language = "English",

volume = "27",

pages = "835--840",

journal = "Neurotoxicology and Teratology",

issn = "0892-0362",

publisher = "Elsevier BV",

number = "6",

}

TY - JOUR

T1 - Changes in sleep-wake cycle after chronic exposure to uranium in rats

AU - Lestaevel, Philippe

AU - Bussy, Cyrill

AU - Paquet, François

AU - Dhieux, Bernadette

AU - Clarençon, Didier

AU - Houpert, Pascale

AU - Gourmelon, Patrick

N1 - 990TZ Times Cited:19 Cited References Count:23

PY - 2005/11

Y1 - 2005/11

N2 - Uranium is a heavy metal known to induce toxicity in kidneys. It is also known to enter the central nervous system, thus inducing neurophysiological effects, after exposure to relatively high concentrations. The effect of chronic uranium exposure (40 mg l- 1 in drinking water, for 90 days) on electroencephalographic architecture has been studied on freely moving rats using a telemetry technique. The main effects of uranium on the sleep-wake cycle were an increase in rapid eye movement sleep (REM-sleep) and theta band power during the light period, as early as Day 30 after exposure commenced. The most probable explanation for these effects is that uranium directly affects the brain. This increase in REM-sleep was previously described in human depression or models of chronically stressed rats and it may be assimilated with some protective or compensatory mechanisms. © 2005 Elsevier Inc. All rights reserved.

AB - Uranium is a heavy metal known to induce toxicity in kidneys. It is also known to enter the central nervous system, thus inducing neurophysiological effects, after exposure to relatively high concentrations. The effect of chronic uranium exposure (40 mg l- 1 in drinking water, for 90 days) on electroencephalographic architecture has been studied on freely moving rats using a telemetry technique. The main effects of uranium on the sleep-wake cycle were an increase in rapid eye movement sleep (REM-sleep) and theta band power during the light period, as early as Day 30 after exposure commenced. The most probable explanation for these effects is that uranium directly affects the brain. This increase in REM-sleep was previously described in human depression or models of chronically stressed rats and it may be assimilated with some protective or compensatory mechanisms. © 2005 Elsevier Inc. All rights reserved.

KW - Chronic exposure

KW - Depression

KW - EEG

KW - Rapid eye movement sleep

KW - Uranium

U2 - 10.1016/j.ntt.2005.07.005

DO - 10.1016/j.ntt.2005.07.005

M3 - Article

SN - 0892-0362

VL - 27

SP - 835

EP - 840

JO - Neurotoxicology and Teratology

JF - Neurotoxicology and Teratology

IS - 6

ER -

Changes in sleep-wake cycle after chronic exposure to uranium in rats

Abstract

Keywords

Access to Document

Fingerprint

Cite this