Characterisation of Tone Oscillations in Placental and Myometrial Arteries from Normal Pregnancies and Those Complicated by Pre-eclampsia and Growth Restriction

M. Sweeney; M. Wareing; T. A. Mills; P. N. Baker; M. J. Taggart

doi:10.1016/j.placenta.2008.01.007

Characterisation of Tone Oscillations in Placental and Myometrial Arteries from Normal Pregnancies and Those Complicated by Pre-eclampsia and Growth Restriction

M. Sweeney, M. Wareing, T. A. Mills, P. N. Baker, M. J. Taggart

Research output: Contribution to journal › Article › peer-review

Abstract

Agonist-induced tone oscillations (rhythmic contractions and relaxations) occur in vascular beds to allow acute regulation of volume flow and thus the delivery of oxygen and nutrients to the tissue. Mechanisms responsible for the control of human placental vasomotor tone and blood flow are poorly characterized. This study aimed to characterise thromboxane-induced tone oscillations in human placental and myometrial arteries. Chorionic plate and myometrial arteries obtained from biopsies at term were mounted for isometric tension measurement. Tone oscillations were observed in chorionic arteries only when exposed to sub-maximal (

Original language	English
Pages (from-to)	356-365
Number of pages	9
Journal	Placenta
Volume	29
Issue number	4
DOIs	https://doi.org/10.1016/j.placenta.2008.01.007
Publication status	Published - Apr 2008

Keywords

Fetal growth restriction
Myometrial artery tone
Nitirc oxide synthase
Nitric oxide
Placental artery tone
Pre-eclampsia
Thromboxane
Tone oscillations
Vascular tone in pregnancy

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10.1016/j.placenta.2008.01.007

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title = "Characterisation of Tone Oscillations in Placental and Myometrial Arteries from Normal Pregnancies and Those Complicated by Pre-eclampsia and Growth Restriction",

abstract = "Agonist-induced tone oscillations (rhythmic contractions and relaxations) occur in vascular beds to allow acute regulation of volume flow and thus the delivery of oxygen and nutrients to the tissue. Mechanisms responsible for the control of human placental vasomotor tone and blood flow are poorly characterized. This study aimed to characterise thromboxane-induced tone oscillations in human placental and myometrial arteries. Chorionic plate and myometrial arteries obtained from biopsies at term were mounted for isometric tension measurement. Tone oscillations were observed in chorionic arteries only when exposed to sub-maximal (",

keywords = "Fetal growth restriction, Myometrial artery tone, Nitirc oxide synthase, Nitric oxide, Placental artery tone, Pre-eclampsia, Thromboxane, Tone oscillations, Vascular tone in pregnancy",

author = "M. Sweeney and M. Wareing and Mills, {T. A.} and Baker, {P. N.} and Taggart, {M. J.}",

year = "2008",

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language = "English",

volume = "29",

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TY - JOUR

T1 - Characterisation of Tone Oscillations in Placental and Myometrial Arteries from Normal Pregnancies and Those Complicated by Pre-eclampsia and Growth Restriction

AU - Sweeney, M.

AU - Wareing, M.

AU - Mills, T. A.

AU - Baker, P. N.

AU - Taggart, M. J.

PY - 2008/4

Y1 - 2008/4

N2 - Agonist-induced tone oscillations (rhythmic contractions and relaxations) occur in vascular beds to allow acute regulation of volume flow and thus the delivery of oxygen and nutrients to the tissue. Mechanisms responsible for the control of human placental vasomotor tone and blood flow are poorly characterized. This study aimed to characterise thromboxane-induced tone oscillations in human placental and myometrial arteries. Chorionic plate and myometrial arteries obtained from biopsies at term were mounted for isometric tension measurement. Tone oscillations were observed in chorionic arteries only when exposed to sub-maximal (

AB - Agonist-induced tone oscillations (rhythmic contractions and relaxations) occur in vascular beds to allow acute regulation of volume flow and thus the delivery of oxygen and nutrients to the tissue. Mechanisms responsible for the control of human placental vasomotor tone and blood flow are poorly characterized. This study aimed to characterise thromboxane-induced tone oscillations in human placental and myometrial arteries. Chorionic plate and myometrial arteries obtained from biopsies at term were mounted for isometric tension measurement. Tone oscillations were observed in chorionic arteries only when exposed to sub-maximal (

KW - Fetal growth restriction

KW - Myometrial artery tone

KW - Nitirc oxide synthase

KW - Nitric oxide

KW - Placental artery tone

KW - Pre-eclampsia

KW - Thromboxane

KW - Tone oscillations

KW - Vascular tone in pregnancy

U2 - 10.1016/j.placenta.2008.01.007

DO - 10.1016/j.placenta.2008.01.007

M3 - Article

SN - 0143-4004

VL - 29

SP - 356

EP - 365

JO - Placenta

JF - Placenta

IS - 4

ER -

Characterisation of Tone Oscillations in Placental and Myometrial Arteries from Normal Pregnancies and Those Complicated by Pre-eclampsia and Growth Restriction

Abstract

Keywords

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