TY - JOUR
T1 - Characteristics of androgen deficiency in Late-onset hypogonadism: Results from the European Male Aging study (emas)
AU - Tajar, Abdelouahid
AU - Huhtaniemi, Ilpo T.
AU - O'Neill, Terence W.
AU - Finn, Joseph D.
AU - Pye, Stephen R.
AU - Lee, David M.
AU - Bartfai, Gyorgy
AU - Boonen, Steven
AU - Casanueva, Felipe F F
AU - Forti, Gianni
AU - Giwercman, Aleksander
AU - Han, Thang S.
AU - Kula, Krzysztof
AU - Labrie, Fernand
AU - Lean, Michael E J
AU - Pendleton, Neil
AU - Punab, Margus
AU - Vanderschueren, Dirk
AU - Wu, Frederick C W
A2 - Pott, C
A2 - Wouters, E
A2 - Nilsson, M
A2 - del Mar Fernandez, M
A2 - Jedrzejowska, M
A2 - Tabo, H-M
A2 - Heredi, A
A2 - Moseley, C
A2 - Petrone, Luisa
A2 - Corona, Giovanni
A2 - Borghs, Herman
A2 - Slowikowska-Hilczer, Jolanta
A2 - Walczak-Jedrzejowska, Renata
A2 - Silman, Alan
A2 - Steer, Philip
A2 - Lage, Mary
A2 - Castro, Ana I
A2 - Földesi, Imre
A2 - Fejes, Imre
A2 - Korrovitz, Paul
A2 - Jiang, Min
N1 - , Arthritis Research UK, United Kingdom
PY - 2012/5
Y1 - 2012/5
N2 - Context: Late-onset hypogonadism (LOH) has been defined as a syndrome in middle-aged and elderly men reporting symptoms in the presence of low testosterone (T). Objective: The objective of the study was to seek objective biochemical and end-organ evidence of androgen deficiency in men classified as having LOH according to our previously published criteria. Design, Setting, and Participants: The design of the study included cross-sectional data from the European Male Aging Study on 2966 community-dwelling men aged 40-79years in eight European countries. Main Outcome Measure(s): Waist circumference, body mass index, muscle mass, estimated heel bone mineral density (eBMD), hemoglobin, insulin sensitivity, physical activity, metabolic syndrome, insulin resistance index, and cardiovascular disease were measured. Results: Sixty-three men (2.1%) were classified as having LOH:36 moderate and 27 severe. They were older and more obese than eugonadal men and had, in proportion to the graded T deficiency, lower muscle mass, eBMD, and hemoglobin, with poorer general health. Both moderate and severe LOH was associated with lower hemoglobin, mid-upper arm circumference, eBMD, physical function (measured by the Short Form-36 questionnaire), slower gait speed and poorer general health. Only men with severe LOH showed significant associations with larger waist circumference (β= 1.93cm; 0.04-3.81), insulin resistance (β= 2.81; 1.39-4.23), and the metabolic syndrome (odds ratio 9.94; 2.73-36.22) after adjustments for confounders. Men with low testosterone only (irrespective of symptoms) showed lesser magnitudes of association with the same end points. Conclusions: LOH is associated with multiple end-organ deficits compatible with androgen deficiency. These data support the existence of a syndrome of LOH in only a minority of aging men, especially those with T below 8 nmol/liter. Copyright © 2012 by The Endocrine Society.
AB - Context: Late-onset hypogonadism (LOH) has been defined as a syndrome in middle-aged and elderly men reporting symptoms in the presence of low testosterone (T). Objective: The objective of the study was to seek objective biochemical and end-organ evidence of androgen deficiency in men classified as having LOH according to our previously published criteria. Design, Setting, and Participants: The design of the study included cross-sectional data from the European Male Aging Study on 2966 community-dwelling men aged 40-79years in eight European countries. Main Outcome Measure(s): Waist circumference, body mass index, muscle mass, estimated heel bone mineral density (eBMD), hemoglobin, insulin sensitivity, physical activity, metabolic syndrome, insulin resistance index, and cardiovascular disease were measured. Results: Sixty-three men (2.1%) were classified as having LOH:36 moderate and 27 severe. They were older and more obese than eugonadal men and had, in proportion to the graded T deficiency, lower muscle mass, eBMD, and hemoglobin, with poorer general health. Both moderate and severe LOH was associated with lower hemoglobin, mid-upper arm circumference, eBMD, physical function (measured by the Short Form-36 questionnaire), slower gait speed and poorer general health. Only men with severe LOH showed significant associations with larger waist circumference (β= 1.93cm; 0.04-3.81), insulin resistance (β= 2.81; 1.39-4.23), and the metabolic syndrome (odds ratio 9.94; 2.73-36.22) after adjustments for confounders. Men with low testosterone only (irrespective of symptoms) showed lesser magnitudes of association with the same end points. Conclusions: LOH is associated with multiple end-organ deficits compatible with androgen deficiency. These data support the existence of a syndrome of LOH in only a minority of aging men, especially those with T below 8 nmol/liter. Copyright © 2012 by The Endocrine Society.
U2 - 10.1210/jc.2011-2513
DO - 10.1210/jc.2011-2513
M3 - Article
C2 - 22419720
SN - 1945-7197
VL - 97
SP - 1508
EP - 1516
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 5
ER -
