TY - JOUR
T1 - Characteristics of secondary, primary, and compensated hypogonadism in aging men: Evidence from the European male ageing study
AU - Tajar, Abdelouahid
AU - Forti, Gianni
AU - O'Neill, Terence W.
AU - Lee, David M.
AU - Silman, Alan J.
AU - Finn, Joseph D.
AU - Bartfai, György
AU - Boonen, Steven
AU - Casanueva, Felipe F.
AU - Giwercman, Aleksander
AU - Han, Thang S.
AU - Kula, Krzysztof
AU - Labrie, Fernand
AU - Lean, Michael E J
AU - Pendleton, Neil
AU - Punab, Margus
AU - Vanderschueren, Dirk
AU - Huhtaniemi, Ilpo T.
AU - Wu, Frederick C W
AU - Petrone, Luisa
AU - Corona, Giovanni
AU - Borghs, Herman
AU - Slowikowska-Hilczer, Jolanta
AU - Walczak-Jedrzejowska, Renata
AU - Steer, Philip
AU - Pye, Stephen
AU - Lage, Mary
AU - Földesi, Imre
AU - Fejes, Imre
AU - Korrovitz, Paul
AU - Jiang, Ming
PY - 2010/4
Y1 - 2010/4
N2 - Context: The diagnosis of late-onset hypogonadism (LOH) in older men with age-related declines in testosterone (T) is currently not well characterized. Objective: Our objective was to investigate whether different forms of hypogonadism can be distinguished among aging men. Design: The study was a cross-sectional survey on 3369 community-dwelling men aged 40-79 yr in eight European centers. Methods: Four groups of subjects were defined: eugonadal (normal T and normal LH), secondary (low T and low/normal LH), primary (low T and elevated LH), and compensated (normal T and elevated LH) hypogonadism. Relationships between the defined gonadal status with potential risk factors and clinical symptoms were investigated by multilevel regression models. Results: Among the men, 11.8, 2.0, and 9.5% were classified into the secondary, primary, and compensated hypogonadism categories, respectively. Older men were more likely to have primary [relative risk ratio (RRR) = 3.04; P
AB - Context: The diagnosis of late-onset hypogonadism (LOH) in older men with age-related declines in testosterone (T) is currently not well characterized. Objective: Our objective was to investigate whether different forms of hypogonadism can be distinguished among aging men. Design: The study was a cross-sectional survey on 3369 community-dwelling men aged 40-79 yr in eight European centers. Methods: Four groups of subjects were defined: eugonadal (normal T and normal LH), secondary (low T and low/normal LH), primary (low T and elevated LH), and compensated (normal T and elevated LH) hypogonadism. Relationships between the defined gonadal status with potential risk factors and clinical symptoms were investigated by multilevel regression models. Results: Among the men, 11.8, 2.0, and 9.5% were classified into the secondary, primary, and compensated hypogonadism categories, respectively. Older men were more likely to have primary [relative risk ratio (RRR) = 3.04; P
U2 - 10.1210/jc.2009-1796
DO - 10.1210/jc.2009-1796
M3 - Article
C2 - 20173018
SN - 1945-7197
VL - 95
SP - 1810
EP - 1818
JO - Journal of Clinical Endocrinology and Metabolism
JF - Journal of Clinical Endocrinology and Metabolism
IS - 4
ER -
