Characterization and evaluation of portable FT-NIR instrumentation for life science measurements

Dimitrios Kalamatianos; Ralph J. Houston; John M. Edmunds; Peter E. Wellstead; Panos Liatsis; Maureen S. Thorniley; Richard J. Dewhurst

doi:10.1117/12.571368

Characterization and evaluation of portable FT-NIR instrumentation for life science measurements

Dimitrios Kalamatianos, Ralph J. Houston, John M. Edmunds, Peter E. Wellstead, Panos Liatsis, Maureen S. Thorniley, Richard J. Dewhurst

Research output: Chapter in Book/Conference proceeding › Conference contribution

Abstract

The current demand for versatile medical diagnostics has created a significant increase in the development of NIR spectroscopic techniques due to the relative transparency of body fluids and soft tissue in this spectral region. Specifically the non-invasive determination of blood substrates is a desirable measurement as a guide to the pathological condition of the patient, since blood forms the primary metabolic transport system for the body. There are well-defined needs for real-time near-infrared (NIR) monitoring instruments for in vivo clinical applications. This paper describes a compact and rugged FT-NIR instrument that has the potential to meet this need. A rapid software development environment was used to implement the active alignment, control and self-calibration algorithms. The current prototype has a spectral range of 500-2300 nm and collects a spectrum in 200 ms. The instrument has been validated with band-pass filters and water spectra. Hemoglobin (Hb) solutions and erythrocyte suspensions have also been measured. The well known water absorbance features around 1400 nm and 1900 nm have been observed along with Hb features around 550 nm and we have verified the published blood spectra.

Original language	English
Title of host publication	Progress in Biomedical Optics and Imaging - Proceedings of SPIE\|Progr. Biomed. Opt. Imaging Proc. SPIE
Editors	R.K. Wang, J.C. Hebden, A.V. Priezzhev, V.V. Tuchin
Pages	35-42
Number of pages	7
Volume	5
DOIs	https://doi.org/10.1117/12.571368
Publication status	Published - 2004
Event	ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics - Silsoe Duration: 1 Jul 2004 → …

Conference

Conference	ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics
City	Silsoe
Period	1/07/04 → …

Keywords

Erythrocytes
FT-NIR spectroscopy
Hemoglobin spectra
Self-calibration

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10.1117/12.571368

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Kalamatianos, D., Houston, R. J., Edmunds, J. M., Wellstead, P. E., Liatsis, P., Thorniley, M. S., & Dewhurst, R. J. (2004). Characterization and evaluation of portable FT-NIR instrumentation for life science measurements. In R. K. Wang, J. C. Hebden, A. V. Priezzhev, & V. V. Tuchin (Eds.), Progress in Biomedical Optics and Imaging - Proceedings of SPIE|Progr. Biomed. Opt. Imaging Proc. SPIE (Vol. 5, pp. 35-42) https://doi.org/10.1117/12.571368

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title = "Characterization and evaluation of portable FT-NIR instrumentation for life science measurements",

abstract = "The current demand for versatile medical diagnostics has created a significant increase in the development of NIR spectroscopic techniques due to the relative transparency of body fluids and soft tissue in this spectral region. Specifically the non-invasive determination of blood substrates is a desirable measurement as a guide to the pathological condition of the patient, since blood forms the primary metabolic transport system for the body. There are well-defined needs for real-time near-infrared (NIR) monitoring instruments for in vivo clinical applications. This paper describes a compact and rugged FT-NIR instrument that has the potential to meet this need. A rapid software development environment was used to implement the active alignment, control and self-calibration algorithms. The current prototype has a spectral range of 500-2300 nm and collects a spectrum in 200 ms. The instrument has been validated with band-pass filters and water spectra. Hemoglobin (Hb) solutions and erythrocyte suspensions have also been measured. The well known water absorbance features around 1400 nm and 1900 nm have been observed along with Hb features around 550 nm and we have verified the published blood spectra.",

keywords = "Erythrocytes, FT-NIR spectroscopy, Hemoglobin spectra, Self-calibration",

author = "Dimitrios Kalamatianos and Houston, {Ralph J.} and Edmunds, {John M.} and Wellstead, {Peter E.} and Panos Liatsis and Thorniley, {Maureen S.} and Dewhurst, {Richard J.}",

year = "2004",

doi = "10.1117/12.571368",

language = "English",

volume = "5",

pages = "35--42",

editor = "R.K. Wang and J.C. Hebden and A.V. Priezzhev and V.V. Tuchin",

booktitle = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE|Progr. Biomed. Opt. Imaging Proc. SPIE",

note = "ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics ; Conference date: 01-07-2004",

}

Kalamatianos, D, Houston, RJ, Edmunds, JM, Wellstead, PE, Liatsis, P, Thorniley, MS & Dewhurst, RJ 2004, Characterization and evaluation of portable FT-NIR instrumentation for life science measurements. in RK Wang, JC Hebden, AV Priezzhev & VV Tuchin (eds), Progress in Biomedical Optics and Imaging - Proceedings of SPIE|Progr. Biomed. Opt. Imaging Proc. SPIE. vol. 5, pp. 35-42, ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics, Silsoe, 1/07/04. https://doi.org/10.1117/12.571368

Characterization and evaluation of portable FT-NIR instrumentation for life science measurements. / Kalamatianos, Dimitrios; Houston, Ralph J.; Edmunds, John M. et al.
Progress in Biomedical Optics and Imaging - Proceedings of SPIE|Progr. Biomed. Opt. Imaging Proc. SPIE. ed. / R.K. Wang; J.C. Hebden; A.V. Priezzhev; V.V. Tuchin. Vol. 5 2004. p. 35-42.

Research output: Chapter in Book/Conference proceeding › Conference contribution

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AU - Wellstead, Peter E.

AU - Liatsis, Panos

AU - Thorniley, Maureen S.

AU - Dewhurst, Richard J.

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N2 - The current demand for versatile medical diagnostics has created a significant increase in the development of NIR spectroscopic techniques due to the relative transparency of body fluids and soft tissue in this spectral region. Specifically the non-invasive determination of blood substrates is a desirable measurement as a guide to the pathological condition of the patient, since blood forms the primary metabolic transport system for the body. There are well-defined needs for real-time near-infrared (NIR) monitoring instruments for in vivo clinical applications. This paper describes a compact and rugged FT-NIR instrument that has the potential to meet this need. A rapid software development environment was used to implement the active alignment, control and self-calibration algorithms. The current prototype has a spectral range of 500-2300 nm and collects a spectrum in 200 ms. The instrument has been validated with band-pass filters and water spectra. Hemoglobin (Hb) solutions and erythrocyte suspensions have also been measured. The well known water absorbance features around 1400 nm and 1900 nm have been observed along with Hb features around 550 nm and we have verified the published blood spectra.

AB - The current demand for versatile medical diagnostics has created a significant increase in the development of NIR spectroscopic techniques due to the relative transparency of body fluids and soft tissue in this spectral region. Specifically the non-invasive determination of blood substrates is a desirable measurement as a guide to the pathological condition of the patient, since blood forms the primary metabolic transport system for the body. There are well-defined needs for real-time near-infrared (NIR) monitoring instruments for in vivo clinical applications. This paper describes a compact and rugged FT-NIR instrument that has the potential to meet this need. A rapid software development environment was used to implement the active alignment, control and self-calibration algorithms. The current prototype has a spectral range of 500-2300 nm and collects a spectrum in 200 ms. The instrument has been validated with band-pass filters and water spectra. Hemoglobin (Hb) solutions and erythrocyte suspensions have also been measured. The well known water absorbance features around 1400 nm and 1900 nm have been observed along with Hb features around 550 nm and we have verified the published blood spectra.

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BT - Progress in Biomedical Optics and Imaging - Proceedings of SPIE|Progr. Biomed. Opt. Imaging Proc. SPIE

A2 - Wang, R.K.

A2 - Hebden, J.C.

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A2 - Tuchin, V.V.

T2 - ALT'03 International Conference on Advanced Laser Technologies: Biomedical Optics

Y2 - 1 July 2004

ER -

Kalamatianos D, Houston RJ, Edmunds JM, Wellstead PE, Liatsis P, Thorniley MS et al. Characterization and evaluation of portable FT-NIR instrumentation for life science measurements. In Wang RK, Hebden JC, Priezzhev AV, Tuchin VV, editors, Progress in Biomedical Optics and Imaging - Proceedings of SPIE|Progr. Biomed. Opt. Imaging Proc. SPIE. Vol. 5. 2004. p. 35-42 doi: 10.1117/12.571368

Characterization and evaluation of portable FT-NIR instrumentation for life science measurements

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Keywords

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