Characterization of a novel human opsin gene with wide tissue expression and identification of embedded and flanking genes on chromosome 1q43

Stephanie Halford, Melanie S. Freedman, James Bellingham, Suzanne L. Inglis, Subathra Poopalasundaram, Bobby G. Soni, Russell G. Foster, David M. Hunt

    Research output: Contribution to journalArticlepeer-review

    Abstract

    As part of an ongoing search to identify novel mammalian photopigments that may mediate nonvisual tasks such as circadian entrainment and acute suppression of pineal melatonin levels, a number of recently cloned nonvisual opsin sequences were used to search dbEST. panopsin (OPN3) was one of the clones identified using this approach. Expression analysis detects two transcripts of approximately 2.1 and 2.5 kb, in a wide range of tissues including brain, liver, and retina, which encode a predicted protein of 403 amino acids. The gene was localized to the region of chromosome 1q43 also encompassing the kynurenine monooxygenase (KMO) and choroideremia-like Rab escort protein 2 (CHML) genes. KMO and panopsin overlap at their 3′ ends but are transcribed in opposite directions. CHML, an intronless gene, lies in intron 1 of panopsin. © 2001 Academic Press.
    Original languageEnglish
    Pages (from-to)203-208
    Number of pages5
    JournalGenomics
    Volume72
    Issue number2
    DOIs
    Publication statusPublished - 1 Mar 2001

    Keywords

    • Amino Acid Sequence
    • Base Sequence
    • Chromosome Mapping
    • Chromosomes, Human, Pair 1
    • DNA
    • Databases, Factual
    • Gene Expression
    • Humans
    • Molecular Sequence Data
    • genetics: Opsin
    • Tissue Distribution

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