Characterization of active and infiltrative tumorous subregions from normal tissue in brain gliomas using multiparametric MRI

Anahita Fathi Kazerooni, Mahnaz Nabil, Mehdi Zeinali Zadeh, Kavous Firouznia, Farid Azmoudeh-Ardalan, Alejandro F. Frangi, Christos Davatzikos, Hamidreza Saligheh Rad

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Targeted localized biopsies and treatments for diffuse gliomas rely on accurate identification of tissue subregions, for which current MRI techniques lack specificity. Purpose: To explore the complementary and competitive roles of a variety of conventional and quantitative MRI methods for distinguishing subregions of brain gliomas. Study Type: Prospective. Population: Fifty-one tissue specimens were collected using image-guided localized biopsy surgery from 10 patients with newly diagnosed gliomas. Field Strength/Sequence: Conventional and quantitative MR images consisting of pre- and postcontrast T1w, T2w, T2-FLAIR, T2-relaxometry, DWI, DTI, IVIM, and DSC-MRI were acquired preoperatively at 3T. Assessment: Biopsy specimens were histopathologically attributed to glioma tissue subregion categories of active tumor (AT), infiltrative edema (IE), and normal tissue (NT) subregions. For each tissue sample, a feature vector comprising 15 MRI-based parameters was derived from preoperative images and assessed by a machine learning algorithm to determine the best multiparametric feature combination for characterizing the tissue subregions. Statistical Tests: For discrimination of AT, IE, and NT subregions, a one-way analysis of variance (ANOVA) test and for pairwise tissue subregion differentiation, Tukey honest significant difference, and Games-Howell tests were applied (P < 0.05). Cross-validated feature selection and classification methods were implemented for identification of accurate multiparametric MRI parameter combination. Results: After exclusion of 17 tissue specimens, 34 samples (AT = 6, IE = 20, and NT = 8) were considered for analysis. Highest accuracies and statistically significant differences for discrimination of IE from NT and AT from NT were observed for diffusion-based parameters (AUCs >90%), and the perfusion-derived parameter as the most accurate feature in distinguishing IE from AT. A combination of “CBV, MD, T2_ISO, FLAIR” parameters showed high diagnostic performance for identification of the three subregions (AUC ∼90%). Data Conclusion: Integration of a few quantitative along with conventional MRI parameters may provide a potential multiparametric imaging biomarker for predicting the histopathologically proven glioma tissue subregions. Level of Evidence: 2. Technical Efficacy: Stage 3. J. Magn. Reson. Imaging 2018;48:938–950.

Original languageEnglish
Pages (from-to)938-950
Number of pages13
JournalJournal of Magnetic Resonance Imaging
Volume48
Issue number4
DOIs
Publication statusPublished - Oct 2018

Keywords

  • glioma
  • imaging biomarker
  • intratumor heterogeneity
  • machine learning
  • multiparametric MRI

Fingerprint

Dive into the research topics of 'Characterization of active and infiltrative tumorous subregions from normal tissue in brain gliomas using multiparametric MRI'. Together they form a unique fingerprint.

Cite this