Characterization of ion channels in stimulus-secretion coupling in pancreatic islets

Carina Ämmälä, Charlotte Kane, Karen E. Cosgrove, Joanna C. Chapman, Albert Aynsley-Green, Keith J. Lindley, Mark J. Dunne

    Research output: Contribution to journalArticlepeer-review

    Abstract

    The regulation of insulin secretion from β-cells of the pancreatic islets of Langerhans is a highly integrated process involving several plasma membrane ion channels. The key to our understanding of the normal process is the hypothesis that glucose-induced closure of K+ channels leads to a depolarization of the cell membrane potential and the opening of voltage-gated Ca2+ channels. Support for this is provided by direct electrophysiological recordings of ion channel activity, and by recent data that have revealed how gene defects in ion channel subunits leads to the loss of regulated insulin secretion. Here, we review the general features of stimulus-response coupling in β-cells, and how novel initiatives are providing key insights into β-cell pathogenesis.
    Original languageEnglish
    Pages (from-to)81-85
    Number of pages4
    JournalDigestion
    Volume58
    Issue number2
    Publication statusPublished - Jul 1997

    Keywords

    • Beta-cell
    • Capacitance
    • Insulin
    • Ion channel
    • Sulphonylurea

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