Characterization of the Network Structure of PEG Diacrylate Hydrogels Formed in the Presence of N-Vinyl Pyrrolidone

Chu-Yi Lee; Fouad Teymour; Heinz Camastral; Nicola Tirelli; Jeffrey A Hubbell; Donald L Elbert; Georgia Papavasiliou

doi:10.1002/mren.201300166

Characterization of the Network Structure of PEG Diacrylate Hydrogels Formed in the Presence of N-Vinyl Pyrrolidone

Chu-Yi Lee, Fouad Teymour, Heinz Camastral, Nicola Tirelli, Jeffrey A Hubbell, Donald L Elbert, Georgia Papavasiliou

Research output: Contribution to journal › Article › peer-review

Abstract

PEGDA hydrogels copolymerized with NVP using free-radical photopolymerization are used in biomedical applications. These networks consist of a poly(acrylate-co-vinyl pyrrolidone) backbone crosslinked with PEG chains whose crosslink density is dependent on the backbone molecular weight and composition. Insight into the network structure and characterization of the backbone molecular weight and composition is achieved by considering hydrogel degradation through ester bond hydrolysis resulting in the release of PEG and poly(acrylic acid-co-vinyl pyrrolidone). A model is developed to determine the influence of kinetic constants and phenomena on the backbone formation and is compared to experimental data. Results indicate that the backbone molecular weight is related to the amount of NVP and unaffected by polymerization time.

Original language	English
Pages (from-to)	314-328
Number of pages	15
Journal	Macromolecular Reaction Engineering
Volume	8
Issue number	4
DOIs	https://doi.org/10.1002/mren.201300166
Publication status	Published - 2014

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title = "Characterization of the Network Structure of PEG Diacrylate Hydrogels Formed in the Presence of N-Vinyl Pyrrolidone",

abstract = "PEGDA hydrogels copolymerized with NVP using free-radical photopolymerization are used in biomedical applications. These networks consist of a poly(acrylate-co-vinyl pyrrolidone) backbone crosslinked with PEG chains whose crosslink density is dependent on the backbone molecular weight and composition. Insight into the network structure and characterization of the backbone molecular weight and composition is achieved by considering hydrogel degradation through ester bond hydrolysis resulting in the release of PEG and poly(acrylic acid-co-vinyl pyrrolidone). A model is developed to determine the influence of kinetic constants and phenomena on the backbone formation and is compared to experimental data. Results indicate that the backbone molecular weight is related to the amount of NVP and unaffected by polymerization time.",

author = "Chu-Yi Lee and Fouad Teymour and Heinz Camastral and Nicola Tirelli and Hubbell, {Jeffrey A} and Elbert, {Donald L} and Georgia Papavasiliou",

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T1 - Characterization of the Network Structure of PEG Diacrylate Hydrogels Formed in the Presence of N-Vinyl Pyrrolidone

AU - Lee, Chu-Yi

AU - Teymour, Fouad

AU - Camastral, Heinz

AU - Tirelli, Nicola

AU - Hubbell, Jeffrey A

AU - Elbert, Donald L

AU - Papavasiliou, Georgia

N1 - Times Cited: 1 Si

PY - 2014

Y1 - 2014

N2 - PEGDA hydrogels copolymerized with NVP using free-radical photopolymerization are used in biomedical applications. These networks consist of a poly(acrylate-co-vinyl pyrrolidone) backbone crosslinked with PEG chains whose crosslink density is dependent on the backbone molecular weight and composition. Insight into the network structure and characterization of the backbone molecular weight and composition is achieved by considering hydrogel degradation through ester bond hydrolysis resulting in the release of PEG and poly(acrylic acid-co-vinyl pyrrolidone). A model is developed to determine the influence of kinetic constants and phenomena on the backbone formation and is compared to experimental data. Results indicate that the backbone molecular weight is related to the amount of NVP and unaffected by polymerization time.

AB - PEGDA hydrogels copolymerized with NVP using free-radical photopolymerization are used in biomedical applications. These networks consist of a poly(acrylate-co-vinyl pyrrolidone) backbone crosslinked with PEG chains whose crosslink density is dependent on the backbone molecular weight and composition. Insight into the network structure and characterization of the backbone molecular weight and composition is achieved by considering hydrogel degradation through ester bond hydrolysis resulting in the release of PEG and poly(acrylic acid-co-vinyl pyrrolidone). A model is developed to determine the influence of kinetic constants and phenomena on the backbone formation and is compared to experimental data. Results indicate that the backbone molecular weight is related to the amount of NVP and unaffected by polymerization time.

U2 - 10.1002/mren.201300166

DO - 10.1002/mren.201300166

M3 - Article

VL - 8

SP - 314

EP - 328

JO - Macromolecular Reaction Engineering

JF - Macromolecular Reaction Engineering

IS - 4

ER -

Characterization of the Network Structure of PEG Diacrylate Hydrogels Formed in the Presence of N-Vinyl Pyrrolidone

Abstract

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