Characterization of the novel HLA-DQB1*06:48 allele by group-specific sequencing

L. Foster; D. Tate; K Poulton

doi:10.1111/iji.12004

Characterization of the novel HLA-DQB1*06:48 allele by group-specific sequencing

L. Foster, D. Tate, K Poulton

Division of Population Health, Health Services Research & Primary Care (L5)

Research output: Contribution to journal › Article › peer-review

Abstract

HLA-DQB1*06:48 has single nucleotide polymorphisms within codons 70 and 62 of exon 2 (GGG>AGG and AAG>AAC) relative to HLA-DQB1*06:02:01 and HLA-DQB1*06:37. This results in amino acid differences (G>R and K>N) that will change the polarity and charge of the encoded antigen and may therefore affect its peptide repertoire.

Original language	English
Pages (from-to)	322-3
Number of pages	2
Journal	International Journal of Immunogenetics
Volume	40
Issue number	4
DOIs	https://doi.org/10.1111/iji.12004
Publication status	Published - Aug 2013

Keywords

Alleles
Amino Acid Substitution
Asian Continental Ancestry Group
Base Sequence
Genetic Variation
HLA-DQ beta-Chains
Histocompatibility Testing
Humans
Male
Polymorphism, Single Nucleotide
Sequence Analysis, DNA
Journal Article

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10.1111/iji.12004

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title = "Characterization of the novel HLA-DQB1*06:48 allele by group-specific sequencing",

abstract = "HLA-DQB1*06:48 has single nucleotide polymorphisms within codons 70 and 62 of exon 2 (GGG>AGG and AAG>AAC) relative to HLA-DQB1*06:02:01 and HLA-DQB1*06:37. This results in amino acid differences (G>R and K>N) that will change the polarity and charge of the encoded antigen and may therefore affect its peptide repertoire.",

keywords = "Alleles, Amino Acid Substitution, Asian Continental Ancestry Group, Base Sequence, Genetic Variation, HLA-DQ beta-Chains, Histocompatibility Testing, Humans, Male, Polymorphism, Single Nucleotide, Sequence Analysis, DNA, Journal Article",

author = "L. Foster and D. Tate and K Poulton",

note = "{\textcopyright} 2012 John Wiley & Sons Ltd.",

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doi = "10.1111/iji.12004",

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T1 - Characterization of the novel HLA-DQB1*06:48 allele by group-specific sequencing

AU - Foster, L.

AU - Tate, D.

AU - Poulton, K

PY - 2013/8

Y1 - 2013/8

N2 - HLA-DQB1*06:48 has single nucleotide polymorphisms within codons 70 and 62 of exon 2 (GGG>AGG and AAG>AAC) relative to HLA-DQB1*06:02:01 and HLA-DQB1*06:37. This results in amino acid differences (G>R and K>N) that will change the polarity and charge of the encoded antigen and may therefore affect its peptide repertoire.

AB - HLA-DQB1*06:48 has single nucleotide polymorphisms within codons 70 and 62 of exon 2 (GGG>AGG and AAG>AAC) relative to HLA-DQB1*06:02:01 and HLA-DQB1*06:37. This results in amino acid differences (G>R and K>N) that will change the polarity and charge of the encoded antigen and may therefore affect its peptide repertoire.

KW - Alleles

KW - Amino Acid Substitution

KW - Asian Continental Ancestry Group

KW - Base Sequence

KW - Genetic Variation

KW - HLA-DQ beta-Chains

KW - Histocompatibility Testing

KW - Humans

KW - Male

KW - Polymorphism, Single Nucleotide

KW - Sequence Analysis, DNA

KW - Journal Article

U2 - 10.1111/iji.12004

DO - 10.1111/iji.12004

M3 - Article

C2 - 23107280

SN - 1744-3121

VL - 40

SP - 322

EP - 323

JO - International Journal of Immunogenetics

JF - International Journal of Immunogenetics

IS - 4

ER -

Characterization of the novel HLA-DQB1*06:48 allele by group-specific sequencing

Abstract

Keywords

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