Characterizing early aggregates formed by an amyloidogenic peptide by mass spectrometry

Harriet L. Cole; Jason M D Kalapothakis; Guy Bennett; Perdita E. Barran; Cait E. MacPhee

doi:10.1002/anie.201003373

Characterizing early aggregates formed by an amyloidogenic peptide by mass spectrometry

Harriet L. Cole, Jason M D Kalapothakis, Guy Bennett, Perdita E. Barran, Cait E. MacPhee

Research output: Contribution to journal › Article › peer-review

Abstract

What floats in the soup? Time-course and ion-mobility nano-electrospray ionization (nESI) mass spectrometry probes the early aggregation states of an amyloidogenic endecapeptide derived from amino acid residues 105-115 of the human plasma protein transthyretin. A wide range of densely packed prefibrillar oligomers 1 ≤ n ≤ 13 are observed in dynamic populations over 8 h. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

Original language	English
Pages (from-to)	9448-9451
Number of pages	3
Journal	Angewandte Chemie - International Edition
Volume	49
Issue number	49
DOIs	https://doi.org/10.1002/anie.201003373
Publication status	Published - 3 Dec 2010

Keywords

amyloids
ion mobility
mass spectrometry
oligomers
polypeptides

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10.1002/anie.201003373

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title = "Characterizing early aggregates formed by an amyloidogenic peptide by mass spectrometry",

abstract = "What floats in the soup? Time-course and ion-mobility nano-electrospray ionization (nESI) mass spectrometry probes the early aggregation states of an amyloidogenic endecapeptide derived from amino acid residues 105-115 of the human plasma protein transthyretin. A wide range of densely packed prefibrillar oligomers 1 ≤ n ≤ 13 are observed in dynamic populations over 8 h. Copyright {\textcopyright} 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

keywords = "amyloids, ion mobility, mass spectrometry, oligomers, polypeptides",

author = "Cole, {Harriet L.} and Kalapothakis, {Jason M D} and Guy Bennett and Barran, {Perdita E.} and MacPhee, {Cait E.}",

year = "2010",

month = dec,

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doi = "10.1002/anie.201003373",

language = "English",

volume = "49",

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journal = "Angewandte Chemie - International Edition",

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T1 - Characterizing early aggregates formed by an amyloidogenic peptide by mass spectrometry

AU - Cole, Harriet L.

AU - Kalapothakis, Jason M D

AU - Bennett, Guy

AU - Barran, Perdita E.

AU - MacPhee, Cait E.

PY - 2010/12/3

Y1 - 2010/12/3

N2 - What floats in the soup? Time-course and ion-mobility nano-electrospray ionization (nESI) mass spectrometry probes the early aggregation states of an amyloidogenic endecapeptide derived from amino acid residues 105-115 of the human plasma protein transthyretin. A wide range of densely packed prefibrillar oligomers 1 ≤ n ≤ 13 are observed in dynamic populations over 8 h. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

AB - What floats in the soup? Time-course and ion-mobility nano-electrospray ionization (nESI) mass spectrometry probes the early aggregation states of an amyloidogenic endecapeptide derived from amino acid residues 105-115 of the human plasma protein transthyretin. A wide range of densely packed prefibrillar oligomers 1 ≤ n ≤ 13 are observed in dynamic populations over 8 h. Copyright © 2010 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

KW - amyloids

KW - ion mobility

KW - mass spectrometry

KW - oligomers

KW - polypeptides

U2 - 10.1002/anie.201003373

DO - 10.1002/anie.201003373

M3 - Article

SN - 1433-7851

VL - 49

SP - 9448

EP - 9451

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

IS - 49

ER -

Characterizing early aggregates formed by an amyloidogenic peptide by mass spectrometry

Abstract

Keywords

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