Characterizing function-structure relationships in the human visual system with functional MRI and diffusion tensor imaging

Ahmed T. Toosy, Olga Ciccarelli, Geoff J M Parker, Claudia A M Wheeler-Kingshott, David H. Miller, Alan J. Thompson

    Research output: Contribution to journalArticlepeer-review

    Abstract

    A key objective in neuroscience is to improve our understanding of the relationship between brain function and structure. We investigated this in the posterior visual pathways of healthy volunteers by applying functional magnetic resonance imaging (fMRI) and diffusion tensor imaging (DTI) with tractography. The optic radiations were segmented using the Probabilistic Index of Connectivity (PICo) tractography algorithm and extracted at several thresholds of connection confidence. The mean fractional anisotropy (FA) of the estimated tracts was found to correlate significantly with fMRI measures of visual cortex activity (induced by a photic stimulation paradigm). The results support the hypothesis that the visual cortical fMRI response is constrained by the external anatomical connections of the subserving optic radiations. © 2004 Elsevier Inc. All rights reserved.
    Original languageEnglish
    Pages (from-to)1452-1463
    Number of pages11
    JournalNeuroImage
    Volume21
    Issue number4
    DOIs
    Publication statusPublished - Apr 2004

    Keywords

    • Diffusion tensor imaging
    • DTI
    • fMRI
    • Functional MRI
    • Optic
    • Radiations
    • Visual cortex
    • Visual system

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