Chemical synthesis of13C-labelled ganglioside Gb3trisaccharide from [U-13C]-D-glucose

H. Shimizu, J.M. Brown, S.W. Homans, R.A. Field

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The interaction of bacterial toxins with their cell surface glycolipid receptors offers scope for therapeutic intervention. Whilst crystal and solution structures of Escherichia coli verotoxin-1 have been reported, the precise nature of the interaction of the glycolipid binding domain of the toxin with its natural ligand, ganglioside Gb3 (Galα1 →4Galβ1 →4Glcβ1 →Cer), remain to be confirmed. To this end we now report the synthesis of the (2-trimethylsilyl)ethyl glycoside of the Gb3 trisaccharide in isotopically enriched form from [U-13C]-D-glucose.
Original languageUndefined
Pages (from-to)9489-9506
Number of pages18
Publication statusPublished - 1998

Research Beacons, Institutes and Platforms

  • Manchester Institute of Biotechnology

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