Cholesterol, an essential molecule: Diverse roles involving cytochrome P450 enzymes

Kirsty J. McLean, Marcus Hans, Andrew W. Munro

    Research output: Contribution to journalArticlepeer-review


    Cholesterol is an essential molecule for eukaryotic life and is an important precursor for a wide range of physiological processes. Biosynthesis and homoeostasis of cholesterol are complex mechanisms that are tightly regulated and interlinked with activities of a number of cytochrome P450 enzymes. These P450s play central critical roles in cholesterol metabolism. Key roles include a rate-limiting reaction in the synthesis of cholesterol itself, and in the oxidative transformations of cholesterol into steroid hormones and bile acids. However, microbial P450s also have important roles that impinge directly on human cholesterol synthesis and oxidation. Recent data reveal that Mycobacterium tuberculosis (which infects more than one-third of the world's human population) uses P450s to initiate breakdown of host cholesterol as an energy source. Microbial P450s also catalyse industrially important transformations in the synthesis of cholesterol-lowering statin drugs, with clear benefits to humans. The present article reviews the various roles of P450s in human cholesterol metabolism, from endogenous P450s through to microbial oxidases that enable catabolism of human cholesterol, or facilitate production of statins that regulate cholesterol production with positive outcomes in cardiovascular disease. ©The Authors Journal compilation ©2012 Biochemical Society.
    Original languageEnglish
    Pages (from-to)587-593
    Number of pages6
    JournalBiochemical Society Transactions
    Issue number3
    Publication statusPublished - Jun 2012


    • Cholesterol
    • Cholesterol homoeostasis
    • Cytochrome P450
    • Statin
    • Steroid
    • Tuberculosis


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