Cholesterol supplementation objectively reduces photosensitivity in the Smith-Lemli-Opitz syndrome

R. M. Azurdia, A. V. Anstey, L. E. Rhodes

    Research output: Contribution to journalArticlepeer-review


    Smith-Lemli-Opitz (SLO) affected children have multiple congenital physical and mental abnormalities; photosensitivity to ultraviolet A (UVA) has recently become a recognized feature. We present a patient with SLO and prominent photosensitivity in whom detailed phototesting has been performed at baseline and following 6 months of cholesterol supplementation. There was significant improvement in the symptoms of photosensitivity, confirmed objectively by phototesting and accompanied by partial correction of the biochemical abnormalities seen in SLO. This case report is the first to show that cholesterol supplementation in SLO can lead to an objective improvement in the associated photosensitivity.
    Original languageEnglish
    Pages (from-to)143-145
    Number of pages2
    JournalBritish Journal of Dermatology
    Issue number1
    Publication statusPublished - 2001


    • Cholesterol
    • Photosensitivity
    • Smith-Lemli-Opitz syndrome


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