Chondrogenic differentiation of adult MSCs

Michelle Griffin, Sandip Hindocha, Wasim S. Khan

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Chondrogenesis is a vital part of adult life, as cartilage is important not only for articulation of joints but also maintenance functions of the body. Chondrogenesis is a five way process of intricate events controlled by specific genes and cell-cell interactions which has been documented over recent years. This review highlights the current literature regarding the process of endochondral ossification and covers the different level of control at agent level. Due to the proliferative nature of chondrogenesis and using chondrocytes for self renewal and repair, current research involves finding ways in which to improve and replicate expansion of chondrocytes. The review summarises ways in which ex vitro expansion can be manipulated using growth factors, external sources and scaffolds. © 2012 Bentham Science Publishers.
    Original languageEnglish
    Pages (from-to)260-265
    Number of pages5
    JournalCurrent Stem Cell Research and Therapy
    Volume7
    Issue number4
    DOIs
    Publication statusPublished - Jul 2012

    Keywords

    • Cartilage
    • Chondrocytes
    • Chondrogenesis
    • Endochondral offification
    • Mesenchymal stem cell

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