Chromosomal aberrations associated with clonal evolution and leukemic transformation in fanconi anemia: Clinical and biological implications

Stefan Meyer, Heidemarie Neitzel, Holger Tönnies

    Research output: Contribution to journalArticlepeer-review

    Abstract

    Fanconi anaemia (FA) is an inherited disease with congenital and developmental abnormalities, bone marrow failure, and extreme risk of leukemic transformation. Bone marrow surveillance is an important part of the clinical management of FA and often reveals cytogenetic aberrations. Here, we review bone marrow findings in FA and discuss the clinical and biological implications of chromosomal aberrations associated with leukemic transformation. © 2012 Stefan Meyer et al.
    Original languageEnglish
    Article number349837
    JournalAnemia
    Volume2012
    DOIs
    Publication statusPublished - 2012

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